1-Propanesulfonic acid, 3-(ethylphenylamino)- | 102636-89-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Propanesulfonic acid, 3-(ethylphenylamino)-
• 英文别名: 3-(N-ethylanilino)propane-1-sulfonic acid
• CAS: 102636-89-5
• 化学式: C₁₁H₁₇NO₃S
• 分子量: 243.32
• InChiKey: HXITYOAFXWBMLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Determination method of biological component and reagent kit used therefor
  申请人：——

  公开号：US20020119507A1

  公开（公告）日：2002-08-29

  The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method of formaldehyde and biological components, such as creatinine, creatine, homocysteine and the like, which produces formaldehyde as a reaction intermediate. In addition, the present invention provides a reagent kit for the above-mentioned determination method. The present invention provides a novel determination method of a homocysteine using transferase utilizing homocysteine and other compound as a pair of substrates. Particularly, the present invention provides a determination method of homocysteine which includes bringing betaine-homocysteine methyltransferase and dimethylglycine oxidase into contact with a sample and measuring produced hydrogen peroxide or formaldehyde. Moreover, the present invention provides novel dimethylglycine oxidase stable to thiol compound, which is suitably used for the measurement. The present invention provides a reagent kit used for any of the above-mentioned determination methods of homocysteines.

  本发明提供了一种新型的谷胱甘肽依赖性甲醛脱氢酶，它使得通过循环反应定量测量甲醛成为可能，并提供了一种测定甲醛和生物成分（如肌酐、肌酸、同型半胱氨酸等）的方法，该方法产生甲醛作为反应中间体。此外，本发明还提供了用于上述测定方法的试剂盒。本发明提供了一种新型的利用同型半胱氨酸和其他化合物作为一对底物的转移酶测定同型半胱氨酸的方法。特别是，本发明提供了一种同型半胱氨酸的测定方法，其中包括将甜菜碱-同型半胱氨酸甲基转移酶和二甲基甘氨酸氧化酶与样品接触，并测量产生的过氧化氢或甲醛。此外，本发明还提供了一种对巯基化合物稳定的新型二甲基甘氨酸氧化酶，适用于测量。本发明提供了用于上述同型半胱氨酸测定方法的试剂盒。
• Verfahren und Reagenz zum Nachweis von Schädigungen bzw. Erkrankungen des Herzens
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0243901A1

  公开（公告）日：1987-11-04

  zum spezifischen und frühen Nachweis von Schädigungen bzw. Erkrankungen des Herzens, insbesondere von akutem Herzinfarkt, wird ein niedermolekularer Metabolit, beispielsweise Creatin oder Creatinphosphat, 2 - 8 Stunden nach dem Auftreten der ersten Symptome bestimmt. Zur Bestimmung des hierbei enzymatisch freigesetzten H202 wird ein Reagenz, das neben einem Elektronen- oder Radikal-Akzeptor ein Anilinderivat als Wasserstoff-Donor beinhaltet, verwendet.

  为了特异性地及早检测心脏损伤或疾病，特别是急性心肌梗塞，可在首发症状出现 2-8 小时后测定低分子量代谢物，如肌酸或磷酸肌酸。 除电子或自由基受体外，还可使用含有苯胺衍生物作为氢供体的试剂来测定在此过程中酶解释放的 H202。
• Novel amino acid substituted 4-aminophenazones for measuring enzyme activity
  申请人：THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

  公开号：EP0346870A2

  公开（公告）日：1989-12-20

  Novel substrates which are amino acid 4-amino phenazones for detecting enzymes, particularly L-gamma-glutamyltransferase, are described. The amino acid gamma-glutamyl-4-aminophenazone reacts with the enzyme to produce 4-aminophenazone which is an amino dye intermediate. The amino dye intermediate is coupled with a second dye intermediate to form a chromogen. The 4-aminophenazone is particularly reacted with a phenolic naphtholic or aniline compound, particularly the phenolic compound 2-hydroxy-3,5-dichlorobenzenesulfonate, to form a red chromogen in the presence of an oxidizing agent, such as bilirubin oxidase.

  描述了用于检测酶，特别是 L-γ-谷氨酰转移酶的氨基酸 4-氨基酚氮酮新型底物。氨基酸γ-谷氨酰-4-氨基酚氮酮与酶反应生成 4-氨基酚氮酮，它是一种氨基染料中间体。氨基染料中间体与第二种染料中间体偶联形成发色剂。4-aminophenazone 与酚类萘化合物或苯胺化合物，特别是酚类化合物 2-羟基-3,5-二氯苯磺酸盐反应，在氧化剂（如胆红素氧化酶）存在下形成红色发色剂。
• Water-soluble methylenebis(dialkylaniline) derivatives and application thereof
  申请人：DOJINDO LABORATORIES

  公开号：EP0553427A1

  公开（公告）日：1993-08-04

  Novel water-soluble methylenebis(dialkylaniline) derivatives of the following general formula and salts thereof are disclosed. They are useful as dye-forming substances in quantitative determination of peroxides in the copresence of peroxidase or the like.    In the formula, R₁ is hydrogen or a substituent selected from lower alkyl and C₂₋₃ sulfoalkyl or hydroxysulfoalkyl; R₂ is C₂₋₃ sulfoalkyl or hydroxysulfoalkyl; and R₃ is lower alkyl.

  本发明公开了以下通式的新型水溶性亚甲基双（二烷基苯胺）衍生物及其盐类。它们可用作染料形成物质，在过氧化物酶或类似物质的共同作用下定量测定过氧化物。 式中，R₁是氢或选自低级烷基和 C₂₋₃磺酰基或羟基磺酰基的取代基；R₂是 C₂₋₃磺酰基或羟基磺酰基；R₃是低级烷基。
• METHOD OF DETERMINING CHOLESTEROL IN HIGH-DENSITY LIPOPROTEIN
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0699767A1

  公开（公告）日：1996-03-06

  A method of determining cholesterol in high-density lipoprotein (HDL) by treating a HDL-containing specimen with a cholesterol ester hydrolase and a cholesterol oxidase or a cholesterol dehydrogenase in the presence of a reagent capable of aggregating lipoproteins other than HDL, and determining the formed hydrogen peroxide or reduced coenzyme.

  一种测定高密度脂蛋白（HDL）中胆固醇的方法，该方法是在能够聚集高密度脂蛋白以外的脂蛋白的试剂存在下，用胆固醇酯水解酶和胆固醇氧化酶或胆固醇脱氢酶处理含高密度脂蛋白的标本，并测定形成的过氧化氢或还原型辅酶。