1-<1-(Naphth-1-yl)-cyclohexyl>-piperidin | 2201-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-<1-(Naphth-1-yl)-cyclohexyl>-piperidin
• 英文别名: 1-(1-naphthalen-1-yl-cyclohexyl)-piperidine；Piperidine, 1-[1-(1-naphthalenyl)cyclohexyl]-；1-(1-naphthalen-1-ylcyclohexyl)piperidine
• CAS: 2201-37-8
• 化学式: C₂₁H₂₇N
• 分子量: 293.452
• InChiKey: VNGCZEMEKQTINU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-哌啶-1-基环己烷甲腈 、 1-溴代萘 在 magnesium 作用下， 生成 1-<1-(Naphth-1-yl)-cyclohexyl>-piperidin
  参考文献：
  名称：

  Arylcyclohexylamines derived from BTCP are potent indirect catecholamine agonists

  摘要：

  N-[1-(2-Benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP)-related molecules were prepared by means of chemical modulation of the 3 rings which constitute this dopamine (DA) and norepinephrine (NE) uptake inhibitor. Tested in vitro (binding to the DA uptake complex and to the PCP receptor sites, inhibition of the synaptosomal uptake of DA and NE) and in vivo (locomotor activity in mice) these molecules showed good homogeneity of action. The newly prepared structures, although formally related to the phencyclidine (PCP) structural model, no longer display significant affinity for the PCP receptor. These compounds behave like a new series of indirect potent stimulants of the dopaminergic and noradrenergic systems leading to potential antidepressive compounds.

  DOI：

  10.1016/0223-5234(93)90124-w

文献信息

• US5248686A
  申请人：——

  公开号：US5248686A

  公开（公告）日：1993-09-28
• Arylcyclohexylamines derived from BTCP are potent indirect catecholamine agonists
  作者：AT Ilagouma、T Maurice、D Duterte-Boucher、E Coderc、J Vignon、J Costentin、JM Kamenka

  DOI：10.1016/0223-5234(93)90124-w

  日期：1993.1

  N-[1-(2-Benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP)-related molecules were prepared by means of chemical modulation of the 3 rings which constitute this dopamine (DA) and norepinephrine (NE) uptake inhibitor. Tested in vitro (binding to the DA uptake complex and to the PCP receptor sites, inhibition of the synaptosomal uptake of DA and NE) and in vivo (locomotor activity in mice) these molecules showed good homogeneity of action. The newly prepared structures, although formally related to the phencyclidine (PCP) structural model, no longer display significant affinity for the PCP receptor. These compounds behave like a new series of indirect potent stimulants of the dopaminergic and noradrenergic systems leading to potential antidepressive compounds.