2-(2-isopropyl-3H-imidazol-4-yl)-ethylamine | 57118-67-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2-isopropyl-3H-imidazol-4-yl)-ethylamine
• 英文别名: 2-(2-Isopropyl-1H-imidazol-4-yl)ethanamine；2-(2-propan-2-yl-1H-imidazol-5-yl)ethanamine
• CAS: 57118-67-9
• 化学式: C₈H₁₅N₃
• mdl: MFCD09038803
• 分子量: 153.227
• InChiKey: VVACTURLJWWFGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases
  申请人：Bloomfield Graham Charles

  公开号：US20080280871A1

  公开（公告）日：2008-11-13

  in free or salt form, wherein R a , R b , R 2 , R 3 , R 4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  在自由或盐形式中，其中Ra，Rb，R2，R3，R4和R5具有规范中指示的含义，对于治疗由磷脂酰肌醇3-激酶介导的疾病是有用的。还描述了含有该化合物的药物组合物以及制备该化合物的过程。
• 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：Bloomfield Graham Charles

  公开号：US20110124624A1

  公开（公告）日：2011-05-26

  Compounds of Formula I: in free or salt form, wherein R a , R b , R 2 , R 3 , R 4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  公式I的化合物：以自由或盐形式存在，其中Ra、Rb、R2、R3、R4和R5的含义如规范中所示，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。还描述了含有这些化合物的制药组合物和制备这些化合物的过程。
• Novel imidazole compounds, process for synthesis thereof, and method of curing epoxy resins using said compounds
  申请人：SHIKOKU CHEMICALS CORPORATION

  公开号：EP0239246A1

  公开（公告）日：1987-09-30

  Imidazole compounds of formula (I) wherein R is an alkyl group having up to 17 carbon atoms or a phenyl group and A is hydrogen are useful as curing agent or curing accelerator for epoxy resins, and can be produced by hydrolizing the acyl derivative wherein is RCO-.

  式 (I) 的咪唑化合物（其中 R 是具有多达 17 个碳原子的烷基或苯基，A 是氢）可用作环氧树脂的固化剂或固化促进剂，并可通过水解其中 RCO- 的酰基衍生物而制得。
• 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES
  申请人：Novartis AG

  公开号：EP1689391A2

  公开（公告）日：2006-08-16
• US7902375B2
  申请人：——

  公开号：US7902375B2

  公开（公告）日：2011-03-08