Piperidine, 1-(1,3,3,5,5-pentamethylcyclohexyl)- | 685088-11-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Piperidine, 1-(1,3,3,5,5-pentamethylcyclohexyl)-
• 英文别名: 1-(1,3,3,5,5-pentamethylcyclohexyl)piperidine
• CAS: 685088-11-3
• 化学式: C₁₆H₃₁N
• 分子量: 237.42
• InChiKey: CBNNDJDPYKEGJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS
  申请人：Vanderbilt University

  公开号：EP2760447A1

  公开（公告）日：2014-08-06
• METHODS OF TREATING CANCER
  申请人：Glaxosmithkline LLC

  公开号：EP2760452A2

  公开（公告）日：2014-08-06
• METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS
  申请人：Vanderbilt University

  公开号：EP2931277A1

  公开（公告）日：2015-10-21
• US9453017B2
  申请人：——

  公开号：US9453017B2

  公开（公告）日：2016-09-27
• [EN] METHODS OF TREATING CANCER<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2013049770A2

  公开（公告）日：2013-04-04

  This invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining at least one of the following in a sample from said human: (a) the presence or absence of a mutation at the alanine 677 (A677) residue in EZH2 in a sample from said human; or (b) the presence or absence of a mutation at the tyrosine 641 (Y641) residue in EZH2; or (c) the presence or absence of an increased level of H3K27me3 as compared to a control, and administering to said human an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof if at least one of said A677 mutation, Y641 mutation, or increased level of H3K27me3 is present in said sample.