Hexahydrobakuchiol | 10309-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Hexahydrobakuchiol
• 英文别名: 4-(3-Ethyl-3,7-dimethyloctyl)phenol；4-(3-ethyl-3,7-dimethyloctyl)phenol
• CAS: 10309-38-3
• 化学式: C₁₈H₃₀O
• 分子量: 262.436
• InChiKey: WTLVMEPXYONHDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• COMPOSITION OF MATERIALS CONTAINING FLUORIDE VARNISH AND ANTIBACTERIAL AGENTS FOR PREVENTION AND TREATMENT OF DENTAL CARIES
  申请人：WONKWANG UNIVERSITY CENTER FOR INDUSTRY-ACADEMY COOPERATION

  公开号：US20180071180A1

  公开（公告）日：2018-03-15

  The present invention relates to a pharmaceutical composition for prevention and treatment of dental caries comprising a fluoride varnish and an antibacterial substance as active ingredients. The fluoride varnish composition comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene according to the present invention exhibits significant antibacterial activities against the strain Streptococcus mutans ( S. mutans ), which causes dental caries. In particular, the composition exhibits remarkable antibacterial activities compared xanthorrhizol, bakuchiol, bavachalcone, isobavachromene, bavachromene or a fluoride varnish. Therefore, the fluoride varnish comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene can be usefully used for prevention and treatment of dental caries.
• [EN] NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH UCH-L1, CONTAINING SAME AS ACTIVE INGREDIENT<br/>[FR] NOUVEAU COMPOSÉ OU SON SEL PHARMACEUTIQUEMENT ACCEPTABLE ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES ASSOCIÉES À UCH-L1, LE CONTENANT EN TANT QUE PRINCIPE ACTIF
  申请人：UNIV EWHA IND COLLABORATION

  公开号：WO2014185561A1

  公开（公告）日：2014-11-20

  본 발명은 UCH-L1 저해 화합물 및 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 UCH-L1 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 의한 화합물은 UCH-L1의 활성의 억제 효과가 우수하고, 특히, 암세포에 대하여 상처 치유 억제 효과가 있고, 세포 독성이 낮으며, 세포 침윤 억제 효과가 우수하므로 UCH-L1 관련 질환인, 암 또는 알츠하이머, 파킨슨 질환과 같은 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.