3-[3-氯-5-(三氟甲基)吡啶-2-基]丙烷-1-胺 | 1021158-95-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-[3-氯-5-(三氟甲基)吡啶-2-基]丙烷-1-胺
• 英文名称: 3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propan-1-amine
• CAS: 1021158-95-1
• 化学式: C₉H₁₀ClF₃N₂
• 分子量: 238.64
• InChiKey: WQOLZOMRHXSDPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[3-氯-5-(三氟甲基)吡啶-2-基]丙烷-1-胺 、 2-三氟甲基苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以59%的产率得到N-{3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propyl}-2-(trifluoromethyl)benzamide
  参考文献：
  名称：

  [EN] N- (3-PYRIDIN-2-YLPROPYL) BENZAMIDE DERIVATIVES AS FUNGICIDES
  [FR] NOUVEAUX DÉRIVÉS DE N-(3-PYRIDINE-2-YLPROPYL)BENZAMIDE

  摘要：

  公开号：

  WO2008046838A3
• 作为产物：
  描述：

  2-{3-[3-chloro-5-(trifiuoromethyl)pyridin-2-yl]propyl}-1H-isoindole-1,3(2H)-dione 在 肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以95%的产率得到3-[3-氯-5-(三氟甲基)吡啶-2-基]丙烷-1-胺
  参考文献：
  名称：

  [EN] N- (3-PYRIDIN-2-YLPROPYL) BENZAMIDE DERIVATIVES AS FUNGICIDES
  [FR] NOUVEAUX DÉRIVÉS DE N-(3-PYRIDINE-2-YLPROPYL)BENZAMIDE

  摘要：

  公开号：

  WO2008046838A3

文献信息

• Amide derivatives as Nav1.7 and Nav1.8 blockers
  申请人：RaQualia Pharma Inc.

  公开号：US11154544B2

  公开（公告）日：2021-10-26

  The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及对电压门控钠通道（如 Nav1.7 和 Nav1.8 通道）具有阻断活性的酰胺衍生物，它们可用于治疗或预防涉及电压门控钠通道的紊乱和疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的此类疾病中的用途。
• NEW N-(3-PYRIDIN-2-YLPROPYL)BENZAMIDE DERIVATIVES
  申请人：Bayer CropScience SA

  公开号：EP2081900A2

  公开（公告）日：2009-07-29
• EP3487839B1
  申请人：——

  公开号：EP3487839B1

  公开（公告）日：2020-12-23
• N-(3-PYRIDIN-2-YLPROPYL) BENZAMIDE DERIVATIVES AS FUNGICIDES
  申请人：Coqueron Pierre-Yves

  公开号：US20100324102A1

  公开（公告）日：2010-12-23

  A compound of general formula (I) A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.
• Amide Compounds, Preparation Methods and Uses Thereof
  申请人：Liu Changling

  公开号：US20110046152A1

  公开（公告）日：2011-02-24

  Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including ostrinia nubilalis , sugarcane borer, adoxophyes orana fischer von reslerstamm, apple fruit borer, grapholitha inopinata, lymantri dispar l., cnaphalocrocis medinalis, ostrinia furnacalis, helicoverpa assulta, grapholitha inopinata, plutella xylostella, spodoptera exigua, prodenia litura etc., especially for plutella xylostella, spodoptera exigua . The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidal activity which can be used to prevent rice blast, phytophthora infestans, cucumber downy mildew or grey mould of vegetables.