3-[4-(己氧基)苯基]丙酸 | 25131-98-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 3-[4-(己氧基)苯基]丙酸
• 中文别名: 对己氧基苯丙酸
• 英文名称: 3-(4-n-hexyloxyphenyl)propanoic acid
• 英文别名: 3-(4-hexyloxyphenyl)propanoic acidq；3-[p-(hexyloxy)phenyl]propionic acid；3-<4-Hexyloxy-phenyl>-propionsaeure；β-(p-Hexoxyphenyl)-propionsaeure；3-(4-hexoxyphenyl)propanoic acid
• CAS: 25131-98-0
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: XSLSHDVWFGILIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[4-(己氧基)苯基]丙酸 在 palladium diacetate 、 lipase from Pseudomonas Cepacia 作用下， 以 环己烷 为溶剂， 反应 19.0h， 生成
  参考文献：
  名称：

  The effect of vinyl esters on the enantioselectivity of the lipase-catalysed transesterification of alcohols

  摘要：

  The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol I was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alcohol was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, respectively. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalysed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of 1 was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-1 and then the enantioselective hydrolysis of the resultant ester to afford (S)-1. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00083-0
• 作为产物：
  描述：

  对羟基苯丙酸甲酯 生成 3-[4-(己氧基)苯基]丙酸
  参考文献：
  名称：

  Kuchar, Miroslav; Brunova, Bohumila; Rejholec, Vaclav, Collection of Czechoslovak Chemical Communications, 1981, vol. 46, # 5, p. 1173 - 1187

  摘要：

  DOI：

文献信息

• Method for the preparation of esters
  申请人：Aktiebolaget Leo

  公开号：US04180504A1

  公开（公告）日：1979-12-25

  This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.

  这项发明涉及一种改进的酯合成方法，其中使用碳酰胺与酸催化剂作为缩合剂。
• Steroid esters preparation
  申请人：Aktiebolaget Leo

  公开号：US04181669A1

  公开（公告）日：1980-01-01

  This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.

  本发明涉及一种改进的类固醇酯合成方法，其中使用一种卡博二酰胺与酸催化剂相结合作为缩合剂。
• PERFLUOROKETONE COMPOUNDS AND USES THEREOF
  申请人：David Samuel

  公开号：US20100048727A1

  公开（公告）日：2010-02-25

  Novel perfluoroketone compounds of formula [I] and [Ia] are described. Also described are uses thereof, such as for inhibition of phospholipase A 2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and/or inflammatory conditions, such as demyelinating (e.g., multiple sclerosis) and neural injury (e.g., spinal cord injury).

  本文描述了化学式[I]和[Ia]的新型全氟酮化合物。还描述了它们的用途，例如用于抑制磷脂酶A2活性。还描述了它们的治疗用途，例如用于治疗神经疾病和/或炎症疾病，如脱髓鞘（例如多发性硬化症）和神经损伤（例如脊髓损伤）。
• Pharmaceutical composition for alleviating the violence of a mammal comprising nortestosterone derivatives
  申请人：——

  公开号：US20040058898A1

  公开（公告）日：2004-03-25

  The present invention relates to a pharmaceutical composition for alleviating the violence, sublimating the nature and stimulating the appetite of a mammal, including an ostrich, a cat, a dog, a goat, a horse, a lion, a tiger, a leopard, an elephant and pet animals, which violently behaves, cries and does not take feed, comprising an effective amount of one or more metabolic nortestosterone derivative selected from the group consisting of 17&bgr;-hydroxy-4-estren-3-one (19-nortestosterone) and ester derivatives of 17&bgr;-hydroxy-4-estren-3-one (19-nortestosterone) which is administered to said mammal in need of treatment for such conditions.

  本发明涉及一种药物组合物，用于减轻包括鸵鸟、猫、狗、山羊、马、狮、虎、豹、象和宠物动物在内的哺乳动物的暴躁行为、升华天性和刺激食欲，这些哺乳动物暴躁、哭闹和不进食，该药物组合物包含一种或多种有效量的代谢去甲睾酮衍生物，这些衍生物选自17&bgr;-羟基-4-雌烯-3-酮（19-去甲睾酮）和17&bgr;-羟基-4-雌烯-3-酮（19-去甲睾酮）的酯衍生物组成的组；-羟基-4-雌烯-3-酮（19-去甲睾酮）和 17&bgr;-羟基-4-雌烯-3-酮（19-去甲睾酮）的酯类衍生物组成的组中的一种或多种代谢去甲睾酮衍生物，将其施用给需要治疗此类病症的哺乳动物。
• Antiprotozoal quinones. II. Synthesis of 4-amino-1,2-naphthoquinones and related compounds as potential antimalarials
  作者：F. J. Bullock、J. F. Tweedie、D. D. McRitchie、M. A. Tucker

  DOI：10.1021/jm00295a025

  日期：1970.1