雌三醇16,17-二乙酸酯3-苯甲酸酯 | 2508-47-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 雌三醇16,17-二乙酸酯3-苯甲酸酯
• 英文名称: Estriol benzoate diacetate
• 英文别名: [(8R,9S,13S,14S,16R,17R)-16,17-diacetyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate
• CAS: 2508-47-6
• 化学式: C₂₉H₃₂O₆
• 分子量: 476.6
• InChiKey: VQHGRIUWSVCJPX-HSZAMCLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• DENTAL REMEDIES CONTAINING PTH
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1016412A1

  公开（公告）日：2000-07-05

  Dental remedies containing as the active ingredient(s) one or more members selected from among parathyroid hormone (PTH) and its derivatives (1) optionally together with estrogen (2). These remedies are clinically efficacious in virtue of their effects of increasing the bone density in the maxillary alveolar bones, in particular, the supramaxillary alveolar bone and the submaxillary alveolar bone, preventing or treating embrittlement of the maxillary alveolar bones, in particular, the supramaxillary alveolar bone and the submaxillary alveolar bone, promoting regeneration of the maxillary alveolar bones, in particular, the supramaxillary alveolar bone and the submaxillary alveolar bone, increasing the bone density in the whole submaxillary bone and the submaxillary molars after tooth extraction, etc.

  牙科治疗药物，其活性成分为一种或多种选自甲状旁腺激素（PTH）及其衍生物（1），可选择与雌激素（2）一起使用。这些药物具有临床疗效，可以增加上颌牙槽骨，特别是颌上牙槽骨和颌下牙槽骨的骨密度，预防或治疗上颌牙槽骨，特别是颌上牙槽骨的脆化、防止或治疗上颌牙槽骨，特别是颌上牙槽骨和颌下牙槽骨的脆化；促进上颌牙槽骨，特别是颌上牙槽骨和颌下牙槽骨的再生；提高拔牙后整个颌下骨和颌下磨牙的骨密度等。
• Dental therapeutics containing parathyroid hormone
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1721617A2

  公开（公告）日：2006-11-15

  Dental therapeutics containing (1) parathyroid hormone (PTH) or one or more PTH derivatives or (2) parathyroid hormone (PTH) or one or more PTH derivatives and estrogen as an active ingredient or active ingredients have various actions such as increasing the bone density of the jaw alveolar bone portion, particularly the one in the upper jaw or the lower jaw, preventing or treating the weakening of the jaw alveolar bone portion, particularly the one in the upper jaw or the lower jaw, promoting the regeneration of the jaw alveolar bone portion, particularly the one in the upper jaw or the lower jaw, and increasing the bone densities of the whole mandibular bone and the mandibular molar portion after tooth removal; hence, they are clinically effective.

  含有(1)甲状旁腺激素(PTH)或一种或多种PTH衍生物或(2)甲状旁腺激素(PTH)或一种或多种PTH衍生物和雌激素作为活性成分或活性成分的牙科治疗剂具有各种作用，例如增加颚齿槽骨部分，特别是上颚或下颚骨部分的骨密度、预防或治疗颌骨牙槽骨部分（尤其是上颌骨或下颌骨）的衰弱，促进颌骨牙槽骨部分（尤其是上颌骨或下颌骨）的再生，以及增加拔牙后整个下颌骨和下颌骨磨牙部分的骨密度；因此，它们在临床上是有效的。