2-(cyclohexylamino)-3-((furan-2-yl)methyl)quinazolin-4(3H)-one | 1446789-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(cyclohexylamino)-3-((furan-2-yl)methyl)quinazolin-4(3H)-one
• 英文别名: 2-(Cyclohexylamino)-3-(furan-2-ylmethyl)quinazolin-4-one；2-(cyclohexylamino)-3-(furan-2-ylmethyl)quinazolin-4-one
• CAS: 1446789-92-9
• 化学式: C₁₉H₂₁N₃O₂
• 分子量: 323.395
• InChiKey: DCQGSWLXDQIOPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰环已烷 在 溴 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 8.17h， 生成 2-(cyclohexylamino)-3-((furan-2-yl)methyl)quinazolin-4(3H)-one
  参考文献：
  名称：

  An efficient metal-free synthesis of 2-amino-substituted-4(3 H )-quinazolinones

  摘要：

  2-Amino-substituted-4(3H)-quinazolinones have been synthesized via an efficient metal-free reaction between 2-aminobenzamide derivatives and carbonimidic dibromides. The reaction proceeds in the presence of K2CO3 affording cyclized products in good to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.11.085

文献信息

• Reaction of Isatoic Anhydride, Amine, and <i>N,N</i>′-Dialkyl Carbodiimides Under Solvent-Free Conditions: New and Efficient Synthesis of 3-Alkyl-2-(alkylamino)quinazolin-4(3<i>H</i>)-ones
  作者：Mehdi Asadi、Mostafa Ebrahimi、Mohammad Mahdavi、Mina Saeedi、Parviz Rashidi Ranjbar、Farshad Yazdani、Abbas Shafiee、Alireza Foroumadi

  DOI：10.1080/00397911.2012.714042

  日期：2013.9.2

  Heating a mixture of isatoic anhydride, amines, and N,N-dialkyl carbodiimides under solvent-free conditions provided novel 3-alkyl-2-(alkylamino)quinazolin-4(3H)-one derivatives for the first time. The products were obtained in moderate to good yields without formation of any by-products. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
• An efficient metal-free synthesis of 2-amino-substituted-4(3 H )-quinazolinones
  作者：Behrooz Mirza

  DOI：10.1016/j.tetlet.2015.11.085

  日期：2016.1

  2-Amino-substituted-4(3H)-quinazolinones have been synthesized via an efficient metal-free reaction between 2-aminobenzamide derivatives and carbonimidic dibromides. The reaction proceeds in the presence of K2CO3 affording cyclized products in good to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.