Epinephrine Acetate | 97289-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Epinephrine Acetate
• 英文别名: acetic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
• CAS: 97289-42-4
• 化学式: C11H17NO5
• 分子量: 243.26
• InChiKey: CEBXQLPKMNOIHN-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.44
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Intranasal epinephrine formulations and methods for the treatment of disease
  申请人：Aegis Therapeutics, LLC

  公开号：US10682414B2

  公开（公告）日：2020-06-16

  Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.

  提供了由肾上腺素制剂组成的鼻腔给药产品和由此类制剂组成的装置。还提供了使用肾上腺素产品治疗过敏性休克的方法。
• INTRANASAL EPINEPHRINE FORMULATIONS AND METHODS FOR THE TREATMENT OF DISEASE
  申请人：Aegis Therapeutics, LLC

  公开号：EP3678649A1

  公开（公告）日：2020-07-15
• DRY POWDER FORMULATIONS OF EPINEPHRINE AND ASSOCIATED METHODS
  申请人：Belhaven BioPharma Inc.

  公开号：US20220395457A1

  公开（公告）日：2022-12-15

  Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.
• [EN] INTRANASAL EPINEPHRINE FORMULATIONS AND METHODS FOR THE TREATMENT OF DISEASE<br/>[FR] FORMULATIONS D'ÉPINÉPHRINE INTRANASALE ET MÉTHODES DE TRAITEMENT D'UNE MALADIE
  申请人：AEGIS THERAPEUTICS LLC

  公开号：WO2019157099A1

  公开（公告）日：2019-08-15

  Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.
• [EN] DRY POWDER FORMULATIONS OF EPINEPHRINE AND ASSOCIATED METHODS<br/>[FR] FORMULATIONS DE POUDRE SÈCHE D'ÉPINÉPHRINE ET PROCÉDÉS ASSOCIÉS
  申请人：[en]BELHAVEN BIOPHARMA INC.

  公开号：WO2022261453A1

  公开（公告）日：2022-12-15

  Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.