2-phenyl-6-(trifluoromethyl)naphthalene | 1421694-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-phenyl-6-(trifluoromethyl)naphthalene
• 英文别名: 2-Phenyl-6-(trifluoromethyl)naphthalene
• CAS: 1421694-47-4
• 化学式: C₁₇H₁₁F₃
• 分子量: 272.27
• InChiKey: RGDKFUURNJVIKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzaldehyde 、 苯乙炔 在 iron(III) chloride 作用下， 以 1,2-二氯乙烷 为溶剂， 以99%的产率得到2-phenyl-6-(trifluoromethyl)naphthalene
  参考文献：
  名称：

  Iron-catalyzed Benzannulation Reactions of 2-Alkylbenzaldehydes and Alkynes Leading to Naphthalene Derivatives

  摘要：

  An efficient and practical method for the synthesis of naphthalene derivatives via Fe(III)-catalyzed benzannulation of 2-(2-ozoethyl)-benzaldehydes and alkynes has been developed. The system holds the advantages of cheap catalysts, wide substrate scope, and mild reaction conditions.

  DOI：

  10.1021/ol4000394

文献信息

• Iron-catalyzed Benzannulation Reactions of 2-Alkylbenzaldehydes and Alkynes Leading to Naphthalene Derivatives
  作者：Shifa Zhu、Yelin Xiao、Zhengjiang Guo、Huanfeng Jiang

  DOI：10.1021/ol4000394

  日期：2013.2.15

  An efficient and practical method for the synthesis of naphthalene derivatives via Fe(III)-catalyzed benzannulation of 2-(2-ozoethyl)-benzaldehydes and alkynes has been developed. The system holds the advantages of cheap catalysts, wide substrate scope, and mild reaction conditions.