17β-(Pentafluorobenzoyl)amino-5β-androstan-3α-yl l-glutamate | 1408057-09-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17β-(Pentafluorobenzoyl)amino-5β-androstan-3α-yl l-glutamate
• 英文别名: (4S)-4-amino-5-[[(3R,5R,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-17-[(2,3,4,5,6-pentafluorobenzoyl)amino]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-5-oxopentanoic acid
• CAS: 1408057-09-9
• 化学式: C₃₁H₃₉F₅N₂O₅
• 分子量: 614.653
• InChiKey: IJRKSLGSQPCDIQ-LAWYNKPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 盐酸 、 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 、 N,N'-二异丙基碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 24.83h， 生成 17β-(Pentafluorobenzoyl)amino-5β-androstan-3α-yl l-glutamate
  参考文献：
  名称：

  Neuroactive steroids with perfluorobenzoyl group

  摘要：

  During an initial study in searching for the alternative derivatives suitable for photolabeling of neuroactive steroids, perfluorobenzoates and perfluorobenzamides in position 17 of 5 beta-androstan-3 alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. After transformation into glutamates or sulfates, 17 alpha-epimers had comparable inhibitory activity at NMDA receptors to the natural neurosteroid (20-oxo-5 beta-pregnan-3 beta-yl sulfate), however, were more potent (2- to 36-fold) than their 17 beta-substituted analogs. In one case, fluorine in position 4' of perfluorobenzoate group was substituted with azide and activity of the final glutamate was retained comparing with the corresponding perfluorobenzoate. The series was expanded with perfluorobenzoyl derivatives of pregnanolone: Perfluorobenzamide of glutamate and perfluorobenzoate of 11 alpha-hydroxy pregnanolone were prepared and tested. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments. (c) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2012.07.004

文献信息

• Neuroactive steroids with perfluorobenzoyl group
  作者：Ivan Černý、Miloš Buděšínský、Vladimír Pouzar、Vojtěch Vyklický、Barbora Krausová、Ladislav Vyklický

  DOI：10.1016/j.steroids.2012.07.004

  日期：2012.10

  During an initial study in searching for the alternative derivatives suitable for photolabeling of neuroactive steroids, perfluorobenzoates and perfluorobenzamides in position 17 of 5 beta-androstan-3 alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. After transformation into glutamates or sulfates, 17 alpha-epimers had comparable inhibitory activity at NMDA receptors to the natural neurosteroid (20-oxo-5 beta-pregnan-3 beta-yl sulfate), however, were more potent (2- to 36-fold) than their 17 beta-substituted analogs. In one case, fluorine in position 4' of perfluorobenzoate group was substituted with azide and activity of the final glutamate was retained comparing with the corresponding perfluorobenzoate. The series was expanded with perfluorobenzoyl derivatives of pregnanolone: Perfluorobenzamide of glutamate and perfluorobenzoate of 11 alpha-hydroxy pregnanolone were prepared and tested. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments. (c) 2012 Elsevier Inc. All rights reserved.