3-乙基氧杂环丁烷-3-甲醛 | 98485-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环丁烷
• 中文名称: 3-乙基氧杂环丁烷-3-甲醛
• 英文名称: 3-ethyloxetane-3-carbaldehyde
• CAS: 98485-37-1
• 化学式: C₆H₁₀O₂
• mdl: MFCD18382018
• 分子量: 114.144
• InChiKey: WBBLZANXGQZNNM-UHFFFAOYSA-N

物化性质

• 沸点：
  156.1±15.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  3-乙基氧杂环丁烷-3-甲醛 以 乙醚 、 水 为溶剂， 生成
  参考文献：
  名称：

  Insecticidal 1-(alkynylalkyl)-3-cyano-2,6,7-trioxabicyclo[2.2.2]octanes

  摘要：

  The high insecticidal activity and potency at the insect GABA-gated chloride channel of 4-alkyl-3-cyano-2,6,7-trioxabicyclo[2.2.2]octanes with the 1-(4-ethynylphenyl) substituent is also achieved with the corresponding l-(hex-5-ynyl) analogs. Conceptually the four-methylene linkage resembles the spatial characteristics of a phenyl ring and allows the ethynyl group to occupy the same area of receptor space as when attached at the 4-position of an aryl moiety. This is the first example of chloride channel blockers with the ability to replace a phenyl group by a conformationally flexible alkyl linkage and retain a significant portion of the activity.

  DOI：

  10.1021/jf00031a020
• 作为产物：
  描述：

  3-乙基-3-氧杂丁环甲醇 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以82.3%的产率得到3-乙基氧杂环丁烷-3-甲醛
  参考文献：
  名称：

  DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES

  摘要：

  折叠环丙烯-1,2-二酮的二取代3,4-二氨基化合物的一般式(I)已被披露。还披露了包括这些化合物的药物组合物以及使用这些化合物和组合物治疗趋化因子介导的病理的方法。

  公开号：

  US20140309208A1

文献信息

• Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160052884A1

  公开（公告）日：2016-02-25

  The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

  这项发明涉及替代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病的药物，特别是心血管疾病，优选是血栓性或血栓栓塞性疾病、水肿以及眼科疾病。
• 치환된 옥소피리딘 유도체 및 심혈관 장애의 치료에서의 그의 용도
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT 바이엘 파마 악티엔게젤샤프트(519980697332)

  公开号：KR20150137095A

  公开（公告）日：2015-12-08

  본 발명은 하기 화학식 I의 치환된 옥소피리딘 유도체, 및 그의 제조 방법 및 질환, 특히 심혈관 질환, 바람직하게는 혈전성 또는 혈전색전성 질환, 및 부종, 및 또한 안과 장애의 치료 및/또는 예방을 위한 의약의 제조를 위한 그의 용도에 관한 것이다. <화학식 I> 상기 식에서, R1은 하기 화학식의 기이고, 여기서 *는 옥소피리딘 고리에 대한 부착 부위이고, R6은 브로민, 염소, 플루오린, 메틸, 디플루오로메틸, 트리플루오로메틸, 메톡시, 디플루오로메톡시 또는 트리플루오로메톡시이고, R7은 브로민, 염소, 플루오린, 시아노, 니트로, 히드록실, 메틸, 디플루오로메틸, 트리플루오로메틸, 메톡시, 에톡시, 디플루오로메톡시, 트리플루오로메톡시, 에티닐, 3,3,3-트리플루오로프로프-1-인-1-일 또는 시클로프로필이다.

  本发明涉及下式I的取代的氧吡啶衍生物、其制备方法及其在制备治疗和/或预防疾病，特别是心血管疾病，优选血栓性或血栓栓塞性疾病和水肿，以及眼科疾病的药物中的用途。<方案 I>在上式中，R1 是下式的基团，其中 * 是氧吡啶环的连接位点，R6 是溴、氯、氟、甲基、二氟甲基、三氟甲基、甲氧基、二氟甲氧基或三氟甲氧基、R7 是溴、氯、氟、氰基、硝基、羟基、甲基、二氟甲基、三氟甲基、甲氧基、乙氧基、二氟甲氧基、三氟甲氧基、乙炔基、3,3,3-三氟丙-1-炔-1-基或环丙基。
• DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US20140309208A1

  公开（公告）日：2014-10-16

  Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated pathologies.

  折叠环丙烯-1,2-二酮的二取代3,4-二氨基化合物的一般式(I)已被披露。还披露了包括这些化合物的药物组合物以及使用这些化合物和组合物治疗趋化因子介导的病理的方法。
• Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US09434690B2

  公开（公告）日：2016-09-06

  The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

  本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备药物治疗和/或预防疾病，特别是心血管疾病，优选血栓性或栓塞性疾病和水肿，以及眼科疾病的用途。
• Substituted oxopyridine derivatives and use thereof cardiovascular disorders
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US10183932B2

  公开（公告）日：2019-01-22

  The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

  本发明涉及取代的氧吡啶衍生物及其制备工艺，还涉及其用于制备治疗和/或预防疾病的药物，尤其是心血管疾病，最好是血栓性或血栓栓塞性疾病和水肿，以及眼科疾病。