5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-amine | 1025027-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-amine
• 英文别名: 5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-amine
• CAS: 1025027-56-8
• 化学式: C₁₇H₁₃N₅S
• 分子量: 319.4
• InChiKey: OSVSUYVNUCYIQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR<br/>[FR] NOUVEAUX COMPOSES DE TRIAZOLE ET D'OXAZOLE, INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT
  申请人：PFIZER PROD INC

  公开号：WO2004026863A1

  公开（公告）日：2004-04-01

  Novel thiazole derivatives of formula I a - c, intermediates fo their preparation, pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-βsignaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  描述了公式I a - c的新噻唑衍生物，其制备的中间体，含有它们的药物组合物以及它们的药用。本发明的化合物是转化生长因子（'TGF'）-β信号通路的有效抑制剂。它们在治疗各种与TGF相关的疾病状态中非常有用，例如癌症和纤维化疾病。
• Novel oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
  申请人：Pfizer Inc

  公开号：US20040110797A1

  公开（公告）日：2004-06-10

  Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-&bgr; signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明涉及新型噁唑和噻唑化合物，包括其衍生物，以及制备它们的中间体，含有它们的制药组合物以及它们的药用用途。本发明所述化合物是转化生长因子（“TGF”）-β信号通路的有效抑制剂。它们可用于治疗各种与TGF相关的疾病状态，包括例如癌症和纤维化疾病。
• NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR
  申请人：Pfizer Products Inc.

  公开号：EP1542994A1

  公开（公告）日：2005-06-22
• NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR
  申请人：Pfizer Products Inc.

  公开号：EP1542994B1

  公开（公告）日：2009-04-29
• US7273936B2
  申请人：——

  公开号：US7273936B2

  公开（公告）日：2007-09-25