甲磺酸,2-甲氧基苯酚 | 98910-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 甲磺酸,2-甲氧基苯酚
• 英文名称: Phenol, 2-methoxy-, methanesulfonate
• 英文别名: methanesulfonic acid;2-methoxyphenol
• CAS: 98910-57-7
• 化学式: C8H12O5S
• 分子量: 220.25
• InChiKey: UVPOCNWLDQDTBF-UHFFFAOYSA-N

物化性质

• 沸点：
  336.0±34.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF
  申请人：Mercier Claude

  公开号：US20130066097A1

  公开（公告）日：2013-03-14

  A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl.

  描述了一种制备5-卤酚的过程，其邻位取代为电子给予基团。还描述了一种制备邻位取代酚的磺酸酯的过程，该酚是邻位取代的5-卤酚的合成中间体。制备邻位取代酚的过程，该酚的邻位取代为电子给予基团，并以磺酸酯的形式保护，可以包括在Lewis酸的存在下，将邻位取代为电子给予基团的酚与磺化试剂反应。制备邻位取代为电子给予基团的5-卤酚的过程可以包括以下步骤：首先，制备如上所述的邻位取代为电子给予基团并以磺酸酯形式保护的酚；其次，在前述步骤中获得的保护酚中间体中，在电子给予基团对位进行卤代反应；最后，去除磺酸酯功能以得到羟基。
• [EN] PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'UN 5-HALOGÉNOPHÉNOL ORTHO-SUBSTITUÉ ET SON INTERMÉDIAIRE DE SYNTHÈSE
  申请人：RHODIA CHINA CO LTD

  公开号：WO2011143819A1

  公开（公告）日：2011-11-24

  Disclosed a process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester which comprises reacting a phenol ortho- substituted by an electron-donating group with a sulphonylating agent in the presence of an effective amount of a Lewis acid and a process for preparing a 5-halophenol ortho- substituted which comprises a firste step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above, a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group, and a third step of deprotecting the sulphonic ester function to hydroxyl

  揭示了一种制备含电子给体基团的酚邻位取代的过程，并以磺酸酯形式保护，包括在有效量的Lewis酸存在下，将含电子给体基团的酚邻位取代物与磺化试剂反应的过程，以及一种制备5-卤代酚邻位取代的过程，包括第一步制备如上所述的含电子给体基团的酚邻位取代物并以磺酸酯形式保护，第二步在前一步得到的受保护酚中间体上对位于电子给体基团的位置进行卤代反应，第三步去除磺酸酯功能以得到羟基。
• US8975431B2
  申请人：——

  公开号：US8975431B2

  公开（公告）日：2015-03-10