4-(4-methoxyphenyl)-N-(4-oxopyrido[1,2-a]pyrimidin-3-yl)piperazine-1-carboxamide | 1408240-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-methoxyphenyl)-N-(4-oxopyrido[1,2-a]pyrimidin-3-yl)piperazine-1-carboxamide
• CAS: 1408240-80-1
• 化学式: C₂₀H₂₁N₅O₃
• 分子量: 379.418
• InChiKey: WALQXVUSSKYZER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 在 盐酸 、 sodium azide 、 氯甲酸乙酯 、 三乙胺 作用下， 以 二苯醚 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 24.25h， 生成 4-(4-methoxyphenyl)-N-(4-oxopyrido[1,2-a]pyrimidin-3-yl)piperazine-1-carboxamide
  参考文献：
  名称：

  Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors

  摘要：

  Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluated for their in vitro FP-2 inhibitory potential. Compounds (14,17) showed excellent FP-2 inhibition and can serve as lead compounds for further development of potent FP-2 inhibitors as potential antimalarial drugs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.09.008

文献信息

• Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
  作者：U.R. Mane、H. Li、J. Huang、R.C. Gupta、S.S. Nadkarni、R. Giridhar、P.P. Naik、M.R. Yadav

  DOI：10.1016/j.bmc.2012.09.008

  日期：2012.11

  Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluated for their in vitro FP-2 inhibitory potential. Compounds (14,17) showed excellent FP-2 inhibition and can serve as lead compounds for further development of potent FP-2 inhibitors as potential antimalarial drugs. (C) 2012 Elsevier Ltd. All rights reserved.