5-Bromo-10-hydroxy-benzo[g]chromen-2-one | 918300-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 5-Bromo-10-hydroxy-benzo[g]chromen-2-one
• 英文别名: 5-Bromo-10-hydroxy-2H-naphtho[2,3-b]pyran-2-one；5-bromo-10-hydroxybenzo[g]chromen-2-one
• CAS: 918300-47-7
• 化学式: C₁₃H₇BrO₃
• 分子量: 291.101
• InChiKey: ITHDNMCWRIWUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-Hydroxy-benzo[g]chromen-2-one 在 sulfonic acid functionalized silica N-溴代丁二酰亚胺(NBS) 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 0.5h， 以97%的产率得到5-Bromo-10-hydroxy-benzo[g]chromen-2-one
  参考文献：
  名称：

  An efficient, rapid and regioselective nuclear bromination of aromatics and heteroaromatics with NBS using sulfonic-acid-functionalized silica as a heterogeneous recyclable catalyst

  摘要：

  A simple, efficient and rapid method has been developed for high-yielding regioselective nuclear monobromination of aromatic and heteroaromatic compounds using NBS in the presence of sulfonic-acid-functionalized silica at room temperature. The catalyst works under heterogeneous conditions and can be recycled. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.029

文献信息

• An efficient, rapid and regioselective nuclear bromination of aromatics and heteroaromatics with NBS using sulfonic-acid-functionalized silica as a heterogeneous recyclable catalyst
  作者：Biswanath Das、Katta Venkateswarlu、Maddeboina Krishnaiah、Harish Holla

  DOI：10.1016/j.tetlet.2006.10.029

  日期：2006.12

  A simple, efficient and rapid method has been developed for high-yielding regioselective nuclear monobromination of aromatic and heteroaromatic compounds using NBS in the presence of sulfonic-acid-functionalized silica at room temperature. The catalyst works under heterogeneous conditions and can be recycled. (c) 2006 Elsevier Ltd. All rights reserved.