3-二甲基氨基丙基脲 | 31506-43-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 3-二甲基氨基丙基脲
• 中文别名: N-[3-(二甲基氨基)丙基]脲
• 英文名称: 1-[3-(dimethylamino)propyl]urea
• 英文别名: 3-dimethylaminopropylurea；(3-dimethylamino-propyl)-urea；(3-Dimethylamino-propyl)-harnstoff；N-(3-dimethylaminopropyl)-urea；N-(3-dimethylaminopropyl)urea；3-(Dimethylamino)propylurea
• CAS: 31506-43-1
• 化学式: C₆H₁₅N₃O
• mdl: MFCD00270755
• 分子量: 145.205
• InChiKey: IIVBUJGYWCCLNG-UHFFFAOYSA-N

物化性质

• 沸点：
  224.4±32.0℃ (760 Torr)
• 密度：
  1.005±0.06 g/cm3 (20 ºC 760 Torr)
• 闪点：
  89.5±25.1℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  3-二甲基氨基丙基脲 、 碘甲烷 生成 trimethyl-(3-ureido-propyl)-ammonium; iodide
  参考文献：
  名称：

  Chiti; Selleri, Farmaco, Edizione Scientifica, 1958, vol. 13, p. 261,282

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium cyanate 、 N,N-二甲基-1,3-二氨基丙烷 生成 3-二甲基氨基丙基脲
  参考文献：
  名称：

  Chiti; Selleri, Farmaco, Edizione Scientifica, 1958, vol. 13, p. 261,282

  摘要：

  DOI：

文献信息

• [EN] INDAZOLOPYRIMIDINONES AS FIBRINOLYSIS INHIBITORS<br/>[FR] INDAZOLOPYRIMIDINONES COMME INHIBITEURS DE LA FIBRINOLYSE
  申请人：BAYER PHARMA AG

  公开号：WO2016173948A1

  公开（公告）日：2016-11-03

  The present application relates to novel substituted indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

  本申请涉及新型取代吲唑吡咯嘧啶酮，其制备方法，以及用于治疗和/或预防疾病的化合物，特别是用于治疗和/或预防患有或不患有基础遗传或获得性止血障碍的患者急性和复发性出血的方法，其中出血与从重经期出血、产后出血、出血性休克、创伤、手术、移植、中风、肝病、遗传性血管性水肿、鼻血、以及血液积聚后的滑膜炎和软骨损伤等一组疾病或医疗干预有关。
• PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
  申请人：Philippe Michel

  公开号：US20100028280A1

  公开（公告）日：2010-02-04

  The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

  该发明涉及一种直发角蛋白纤维的拉直过程，包括：(i)将至少两种变性剂含有的拉直组合物涂抹到角蛋白纤维上的步骤，(ii)使用加热装置将角蛋白纤维的温度升高至110至250°C的步骤。
• NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES
  申请人：Evonik Degussa GmbH

  公开号：US20180194889A1

  公开（公告）日：2018-07-12

  The present invention provides for the use of nitrogen compounds of formula (I) and/or of corresponding quaternized and/or protonated compounds for production of polyurethanes, compositions containing these compounds and polyurethane systems, especially polyurethane foams, which have been obtained using the compounds.

  本发明提供了使用式(I)的氮化合物和/或相应的季铵化和/或质子化化合物用于生产聚氨酯、含有这些化合物的组合物和聚氨酯体系的方法，特别是使用这些化合物获得的聚氨酯泡沫。
• [EN] NOVEL KINASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE KINASES
  申请人：ORIGENIS GMBH

  公开号：WO2014060113A1

  公开（公告）日：2014-04-24

  The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

  本发明涉及一种具有公式（I）的新化合物，能够抑制一个或多个激酶，特别是SYK（脾酪氨酸激酶）、LRRK2（富含亮氨酸重复的激酶2）和/或MYLK（肌球蛋白轻链激酶）或其突变体。这些化合物在治疗多种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和激素相关疾病。
• REACTIVE AMINE CATALYSTS FOR POLYURETHANE APPLICATIONS
  申请人：Air Products and Chemicals, Inc.

  公开号：US20160347901A1

  公开（公告）日：2016-12-01

  Tertiary amine catalysts having isocyanate reactive groups that are capable of forming thermally stable covalent bonds able to withstand temperatures up to 120° C. are disclosed. These catalyst can be used to produce polyurethane foam having the following desirable characteristics: a) very low chemical emissions over a wide range of environmental conditions and isocyanate indexes (e.g. indexes as low as 65 but higher than 60) while meeting all physical property requirements; b) sufficient hydrolytic stability to maintain the catalyst covalently bound to foam without leaching of tertiary amine catalyst when foam is exposed to water or aqueous solutions even at temperatures higher than ambient (temperature range 25° C. to 90° C.); and c) stable contact interface between the polyurethane polymer and other polymers (for example polycarbonate) with minimal migration of tertiary amine catalyst from polyurethane polymer to other polymers yielding no noticeable polymer deterioration at the point of contact even under conditions of heat and humidity.

  揭示了具有异氰酸酯反应基团的三级胺催化剂，能够形成能够承受高达120°C温度的热稳定共价键。这些催化剂可用于生产具有以下理想特性的聚氨酯泡沫：a) 在各种环境条件和异氰酸酯指数（例如指数低至65但高于60）下，化学排放极低，同时满足所有物理性能要求；b) 具有足够的水解稳定性，使催化剂能够共价结合到泡沫中，即使在高于环境温度的条件下，泡沫暴露在水或水溶液中（温度范围为25°C至90°C）也不会渗漏三级胺催化剂；c) 聚氨酯聚合物与其他聚合物（例如聚碳酸酯）之间的稳定接触界面，使三级胺催化剂从聚氨酯聚合物迁移到其他聚合物的最小，即使在热和湿度条件下，接触点处也不会出现明显的聚合物恶化。