2-[(4-chlorophenylamino)naphthalen-1-ylmethyl]cyclohexanone | 920276-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(4-chlorophenylamino)naphthalen-1-ylmethyl]cyclohexanone
• 英文别名: 2-[(4-Chloroanilino)(naphthalen-1-yl)methyl]cyclohexan-1-one；2-[(4-chloroanilino)-naphthalen-1-ylmethyl]cyclohexan-1-one
• CAS: 920276-39-7
• 化学式: C₂₃H₂₂ClNO
• 分子量: 363.887
• InChiKey: WKSDGXWJJDQZID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己酮 、 1-萘甲醛 、 对氯苯胺 在 sodium tetrakis(3,5-trifluoromethylphenyl)borate 作用下， 以 水 为溶剂， 以65%的产率得到2-[(4-chlorophenylamino)naphthalen-1-ylmethyl]cyclohexanone
  参考文献：
  名称：

  Mannich-type reactions in a colloidal solution formed by sodium tetrakis(3,5-trifluoromethylphenyl)borate as a catalyst in water

  摘要：

  Sodium tetrakis(3,5-trifluoromethylphenyl) borate [NaBAr4F] efficiently catalyzed the one-pot, three-component Mannich reaction of ketones with aromatic aldehydes and different anilines in water at an ambient temperature and afforded the corresponding beta-amino carbonyl compounds in good to excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.125

文献信息

• Mannich-type reactions in a colloidal solution formed by sodium tetrakis(3,5-trifluoromethylphenyl)borate as a catalyst in water
  作者：Chi-Tsing Chang、Bei-Sih Liao、Shiuh-Tzung Liu

  DOI：10.1016/j.tetlet.2006.10.125

  日期：2006.12

  Sodium tetrakis(3,5-trifluoromethylphenyl) borate [NaBAr4F] efficiently catalyzed the one-pot, three-component Mannich reaction of ketones with aromatic aldehydes and different anilines in water at an ambient temperature and afforded the corresponding beta-amino carbonyl compounds in good to excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.