3-去氢蜕皮激素 | 39750-00-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 3-去氢蜕皮激素
• 英文名称: 3-Dehydroecdyson
• 英文别名: 3-Dehydroecdysone；(2S,5R,9R,10R,13R,14S,17R)-17-[(2S,3R)-3,6-dihydroxy-6-methylheptan-2-yl]-2,14-dihydroxy-10,13-dimethyl-1,2,4,5,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6-dione
• CAS: 39750-00-0
• 化学式: C₂₇H₄₂O₆
• 分子量: 462.627
• InChiKey: GDSSFVCRVUQMRG-OSCDMYCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  蜕皮激素 在 铂 氧气 作用下， 以 水 为溶剂， 生成 3-去氢蜕皮激素
  参考文献：
  名称：

  Preparation of 3-epi-ecdysone and 3-epi-20-hydroxyecdysone

  摘要：

  3-Dehydro-ecdysone and 3-dehydro-20-hydroxyecdysone were prepared and characterized. Reduction of these compounds with NaBH4 gave 3-epi-ecdysone and 3-epi-20-hydroxyecdysone, which were characterized fully by mass and p.m.r. spectrometry as well as by derivative formation.

  DOI：

  10.1016/0039-128x(78)90073-9

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Natural product derivatives as food supplements and pharmaceuticals
  申请人：Amato K. Daniel

  公开号：US20050191385A1

  公开（公告）日：2005-09-01

  Then present invention provides new and useful derivatives of phyto-derived tetracyclic compounds possessing steroidal-like activity, and in some instances both amino acid/oligo-peptide and steroidal-like activity, uses thereof and methods of production.

  本发明提供了新的、有用的植物来源四环素化合物衍生物，具有类固醇样活性，在某些情况下同时具有氨基酸/寡肽和类固醇样活性，以及其使用和生产方法。
• Heteroaryl-Ketone Fused Azadecalin Glucocorticoid Receptor Modulators
  申请人：Corcept Therapeutics, Inc.

  公开号：US20140038926A1

  公开（公告）日：2014-02-06

  The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

  本发明提供了杂环基酮融合的氮杂十环化合物，以及使用这些化合物作为糖皮质激素受体调节剂的方法。
• Steroidal Ligands and Their Use in Gene Switch Modulation
  申请人：Intrexon Corporation

  公开号：US20140057349A1

  公开（公告）日：2014-02-27

  The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear receptor complexes and one or more steroidal ligands. Further aspects include ligand compositions including therapeutic compositions.

  本发明涉及用于核受体基础诱导基因表达系统的类固醇配体。本发明还涉及利用含有一个或多个核受体复合物和一个或多个类固醇配体的系统调节感兴趣的基因表达的方法。进一步方面包括包含治疗组合物的配体组合物。
• HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
  申请人：Corcept Therapeutics, Inc.

  公开号：US20150080389A1

  公开（公告）日：2015-03-19

  The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

  本发明提供了杂环酰酮融合的氮杂十二烷化合物以及使用这些化合物作为糖皮质激素受体调节剂的方法。