3-吗啉-4-基-1,2-二苯基-丙烷-1-酮 | 32525-40-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 3-吗啉-4-基-1,2-二苯基-丙烷-1-酮
• 英文名称: 3-morpholin-4-yl-1,2-diphenyl-propan-1-one
• 英文别名: 3-morpholino-1,2-diphenyl-propan-1-one；3-Morpholino-1,2-diphenyl-propan-1-on；[2-(morpholino)-1-(phenyl)ethyl]-(phenyl)-ketone；N-<2-Phenyl-2-benzoyl-ethyl>-morpholin；α-Phenyl-ss-(N-morpholyl)-propiophenon；3-Morpholino-2-phenyl-propiophenone；3-morpholin-4-yl-1,2-diphenylpropan-1-one
• CAS: 32525-40-9
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: MFEJFAWVQXBYRU-UHFFFAOYSA-N

物化性质

• 熔点：
  124 °C
• 沸点：
  449.3±40.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-吗啉-4-基-1,2-二苯基-丙烷-1-酮 以 乙醚 为溶剂， 以98%的产率得到2-morpholino-1,3-diphenylcyclopropanol
  参考文献：
  名称：

  The influence of substituents on the photochemical generation and stability of 2-morpholinocyclopropanols

  摘要：

  By irradiation in oxygen-free ether alpha- or beta-substituted beta-morpholinopropiophenones 1a-c form the corresponding cyclopropanols 2 with 1-aryl and 2-morpholino group in a relative cis-configuration in high yields. The photocyclization of pure 1a-c enantiomers proceeds enantioselectively under these conditions. In methanol and presence of oxygen electronically excited 1c-h are converted to enaminones 3c-h via oxidation of intermediate cyclopropanols 2c-h. In the presence of electron-acceptor molecules this reaction apparently follows a SET mechanism.

  DOI：

  10.1016/s0040-4039(00)61688-x
• 作为产物：
  描述：

  二苯基乙酮 在 sodium hydroxide 、 苯 作用下， 生成 3-吗啉-4-基-1,2-二苯基-丙烷-1-酮
  参考文献：
  名称：

  Matti; Reynaud, Bulletin de la Societe Chimique de France, 1954, p. 603,606

  摘要：

  DOI：

文献信息

• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。
• Antispasmodics. II. Tertiary β-Amino Alcohols
  作者：J. J. Denton、Virginia A. Lawson、W. B. Neier、R. J. Turner

  DOI：10.1021/ja01174a043

  日期：1949.6
• Secondary and Tertiary Amino Ketones and Alcohols Derived from Desoxybenzoin and 1,2-Diphenylethanol.¹ Ring-Chain Tautomerism of the α-(β-Hydroxyethylamino) Ketones²
  作者：Robert E. Lutz、James A. Freek、Robert S. Murphey

  DOI：10.1021/ja01186a012

  日期：1948.6
• Synthesis and separation of diastereoisomeric 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols and their hydrochlorides
  作者：G. A. Gevorgyan、N. K. Gasparyan、A. G. Agababyan、G. A. Panosyan

  DOI：10.1134/s1070428008090170

  日期：2008.9

  1-Aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols were synthesized by reduction of the corresponding 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ones with lithium tetrahydridoaluminate, and the products were separated into erythro and threo isomers by fractional crystallization. Their relative configuration and diastereoisomeric purity was determined by H-1 NMR spectroscopy.
• Casagrande; Ferrari, Farmaco, Edizione Scientifica, 1966, vol. 21, # 10, p. 713 - 722
  作者：Casagrande、Ferrari

  DOI：——

  日期：——