N-[(1R)-2-hydroxy-1-(4-hydroxyphenyl)ethyl]octadec-9-enamide | 709672-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[(1R)-2-hydroxy-1-(4-hydroxyphenyl)ethyl]octadec-9-enamide
• CAS: 709672-24-2
• 化学式: C₂₆H₄₃NO₃
• 分子量: 417.6
• InChiKey: VHPCPWCSVSTMNK-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  30
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation
  申请人：Universität Bern

  公开号：EP2952188A1

  公开（公告）日：2015-12-09

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

  本发明涉及一种由以下通式（1）组成的化合物，用于治疗精神或神经疾病和炎症，尤其是神经炎症： 其中 R1、R2 和 R3 各自独立地选自烷基、烷氧基、烯基、炔基、环烷基、芳基、杂环或杂芳基。
• Substituted 2-imino-1,3-thiazolidin-4-ones as N-arachidonoylethanolamine cellular uptake inhibitors
  申请人：UNIVERSITAT BERN

  公开号：US10155754B2

  公开（公告）日：2018-12-18

  The invention relates to a compound comprising the following general formula (1): and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

  本发明涉及一种由以下通式 (1) 组成的化合物： 式 1）其中 R1、R2 和 R3 各自独立地选自烷基、烷氧基、烯基、炔基、环烷基、芳基、杂环或杂芳基。
• THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION
  申请人：Universität Bern

  公开号：EP3148990A1

  公开（公告）日：2017-04-05
• THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION
  申请人：Universität Bern

  公开号：EP3148541A1

  公开（公告）日：2017-04-05
• [EN] THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION<br/>[FR] THIAZOLIDINONES EN TANT QU'INHIBITEURS D'ABSORPTION D'ANANDAMIDE CELLULAIRE ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES PSYCHIATRIQUES OU NEUROLOGIQUES ET DE L'INFLAMMATION, EN PARTICULIER LA NEURO-INFLAMMATION
  申请人：UNIVERSITÄT BERN

  公开号：WO2015181336A1

  公开（公告）日：2015-12-03

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R 2 and R 3 are selected independently from each other from alkyl, alkoxy, alkenyl,alkynyl,cycloalkyl, aryl,heterocycle or heteroaryl.