甲萘氢醌二丁酸酯 | 53370-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 甲萘氢醌二丁酸酯
• 中文别名: 2-甲基萘-1,4-二基二丁酸酯
• 英文名称: 1,4-bis-butyryloxy-2-methyl-naphthalene
• 英文别名: (2-Methyl-naphthalindiyl-(1.4))-dibutyrat；1,4-Bis-butyryloxy-2-methyl-naphthalin；(2-Methyl-naphthylen-(1.4))-dibutyrat；1.4-Dibutyryloxy-2-methyl-naphthalin；Menadiol dibutyrate；(4-butanoyloxy-3-methylnaphthalen-1-yl) butanoate
• CAS: 53370-44-8
• 化学式: C₁₉H₂₂O₄
• 分子量: 314.381
• InChiKey: TUWJQNVAGYRRHA-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid
• 熔点：
  53°C

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915900090

反应信息

• 作为产物：
  描述：

  丁酸酐 、 甲萘醌 在 sodium butyrate 、 锌 作用下， 生成 甲萘氢醌二丁酸酯
  参考文献：
  名称：

  Vitamin K-Active Derivatives of 2-Methyl-1,4-naphthohydroquinone

  摘要：

  DOI：

  10.1021/ja01858a043

文献信息

• Solvent systems for pharmaceutical agents
  申请人：——

  公开号：US20020102280A1

  公开（公告）日：2002-08-01

  The invention provides compositions, solvent systems, and methods for solubilizing compounds which are otherwise difficult to solubilize. The invention involves the use of a structured fluid (e.g. a liquid crystalline phase, an L1 phase, an L2 phase, an L3 phase, an emulsion, or a microemulsion), comprising a polar solvent, a lipid or a surfactant, and an essential oil or a dissolution/solubilization agent.

  这项发明提供了用于溶解那些通常难以溶解的化合物的组合物、溶剂系统和方法。该发明涉及使用结构化流体（例如液晶相、L1相、L2相、L3相、乳化液或微乳化液），其中包括极性溶剂、脂质或表面活性剂以及精油或溶解/溶解剂。
• METHODS OF INCREASING THE EXPRESSION YIELD OF VITAMIN K-DEPENDENT PROTEINS
  申请人：Keane Julian

  公开号：US20120322107A1

  公开（公告）日：2012-12-20

  The invention encompasses the use of one or more compounds selected from a list comprising i) reduced forms of vitamin K and/or ii) reduced forms of a vitamin K analog and/or iii) reduced forms of a vitamin K precursor for the expression of one or more functional vitamin K-dependent proteins in cell culture as well as processes for the fermentation of eucaryotic cells expressing one or more vitamin K-dependent proteins wherein one or more compounds selected from a list comprising i) reduced forms of vitamin K and/or ii) reduced forms of a vitamin K analog and/or iii) reduced forms of a vitamin K precursor are added to the cell culture medium before and/or during the fermentation process.

  该发明涵盖了从以下列表中选择的一种或多种化合物的使用，包括i）维生素K的还原形式和/或ii）维生素K类似物的还原形式和/或iii）维生素K前体的还原形式，用于在细胞培养中表达一种或多种功能性维生素K依赖性蛋白质，以及用于发酵表达一种或多种维生素K依赖性蛋白质的真核细胞的过程，在这些过程中，在发酵过程之前和/或期间向细胞培养基中添加从以下列表中选择的一种或多种化合物，包括i）维生素K的还原形式和/或ii）维生素K类似物的还原形式和/或iii）维生素K前体的还原形式。
• Drug releasing coatings for medical devices
  申请人：Lutonix, Inc.

  公开号：EP2092941A2

  公开（公告）日：2009-08-26

  The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

  本发明涉及一种向组织输送治疗剂的医疗器械。该医疗器械的外表面覆盖有一层。该层含有治疗剂和添加剂。添加剂有亲水部分和疏水部分，治疗剂不包裹在胶束中，也不封装在颗粒或控释载体中。
• Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
  申请人：Lutonix, Inc.

  公开号：EP2500044A2

  公开（公告）日：2012-09-19

  The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.

  本发明涉及一种可在数秒至数分钟内向组织快速输送治疗剂的涂层医疗器械。该医疗器械的外表面覆盖有一层涂层。该层含有治疗剂、造影剂和添加剂。
• Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
  申请人：Lutonix, Inc.

  公开号：EP2500045A2

  公开（公告）日：2012-09-19

  The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. in further embodiments, the chemical compound is water-soluble.

  本发明涉及一种可在数秒至数分钟内向组织快速输送治疗剂的涂层医疗器械。该医疗器械的外表面覆盖有一层涂层。该层含有治疗剂、油、脂肪酸和脂质中的至少一种以及添加剂。在某些实施例中，添加剂具有亲水性部分和药物亲和性部分，其中药物亲和性部分是疏水性部分、通过氢键与治疗剂具有亲和性的部分、通过电荷与治疗剂具有亲和性的部分以及通过范德华相互作用与治疗剂具有亲和性的部分中的至少一种。在实施例中，添加剂是表面活性剂和化合物中的至少一种。