N⁴-(4-chloro-phenyl)-N²,N²-dimethyl-[1,3,5]triazine-2,4,6-triyltriamine | 61912-50-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N⁴-(4-chloro-phenyl)-N²,N²-dimethyl-[1,3,5]triazine-2,4,6-triyltriamine
• 英文别名: N⁴-(4-Chlor-phenyl)-N²,N²-dimethyl-[1,3,5]triazin-2,4,6-triyltriamin；N~4~-(4-Chlorophenyl)-N~2~,N~2~-dimethyl-1,3,5-triazine-2,4,6-triamine；4-N-(4-chlorophenyl)-2-N,2-N-dimethyl-1,3,5-triazine-2,4,6-triamine
• CAS: 61912-50-3
• 化学式: C₁₁H₁₃ClN₆
• 分子量: 264.717
• InChiKey: ITUUACBUWVMMIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• 1,3,5-TRIAZINE-2,4,6-TRIAMINE COMPOUND OR PHARMACEUTICAL ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：HanAll Biopharma Co., Ltd.

  公开号：EP2197858B1

  公开（公告）日：2014-07-02
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Baron Alain D.

  公开号：US20130095140A1

  公开（公告）日：2013-04-18

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US20140341986A1
  申请人：——

  公开号：US20140341986A1

  公开（公告）日：2014-11-20
• BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Anji Pharma (US) LLC

  公开号：US20220151957A1

  公开（公告）日：2022-05-19

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.