1-Cyclohexyl-3,4,7-trioxa-bicyclo[4.1.0]heptane | 681855-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 1-Cyclohexyl-3,4,7-trioxa-bicyclo[4.1.0]heptane
• 英文别名: 1-Cyclohexyl-3,4,7-trioxabicyclo[4.1.0]heptane；1-cyclohexyl-3,4,7-trioxabicyclo[4.1.0]heptane
• CAS: 681855-89-0
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.235
• InChiKey: YPFQXQNMEIJOAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-cyclohexyl-3,6-dihydro-1,2-dioxine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-Cyclohexyl-3,4,7-trioxa-bicyclo[4.1.0]heptane
  参考文献：
  名称：

  Design of endoperoxides with anti-Candida activity

  摘要：

  Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides I are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.021

文献信息

• Design of endoperoxides with anti-Candida activity
  作者：Thomas D. Avery、Peter I. Macreadie、Ben W. Greatrex、Tony V. Robinson、Dennis K. Taylor、Ian G. Macreadie

  DOI：10.1016/j.bmc.2006.10.021

  日期：2007.1.1

  Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides I are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. (c) 2006 Elsevier Ltd. All rights reserved.