3-氨基-4-哌啶-1-苯甲酸 | 26586-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 3-氨基-4-哌啶-1-苯甲酸
• 英文名称: 3-Amino-4-piperidino-benzoesaeure
• 英文别名: 3-Amino-4-piperidin-1-yl-benzoic acid；3-amino-4-piperidin-1-ylbenzoic acid
• CAS: 26586-27-6
• 化学式: C₁₂H₁₆N₂O₂
• mdl: MFCD02225752
• 分子量: 220.271
• InChiKey: DFGNBCGBUAHIPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  5-cyanofuran-2-carbonyl chloride 、 3-氨基-4-哌啶-1-苯甲酸 在 PS-morpholine 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 3-(2-Cyanofuran-5-carboxamido)-4-(piperidin-1-yl)benzoic acid
  参考文献：
  名称：

  Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

  摘要：

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.057
• 作为产物：
  描述：

  3-硝基-4-哌啶-1-苯甲酸 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 生成 3-氨基-4-哌啶-1-苯甲酸
  参考文献：
  名称：

  Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

  摘要：

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.057

文献信息

• [EN] COMPOUNDS AND METHODS OF ACTIVATING LIPOPROTEIN LIPASE<br/>[FR] COMPOSÉS ET PROCÉDÉS D'ACTIVATION DE LIPOPROTÉINE LIPASE
  申请人：METREA BIOSCIENCES INC

  公开号：WO2022159445A1

  公开（公告）日：2022-07-28

  The present disclosure is generally directed to activators of lipoprotein lipase useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I), or a pharmaceutically acceptable salt, isomer, solvate, prodrug, or tautomer thereof.

  本公开涉及的是脂蛋白脂酶激活剂，其具有公式(I)或其药学上可接受的盐、异构体、溶剂合物、前药或互变异构体，在治疗受该酶调节的疾病和疾病方面具有用途。
• Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents
  作者：Raymond J. Patch、Benjamin M. Brandt、Davoud Asgari、Nand Baindur、Naresh K. Chadha、Taxiarchis Georgiadis、Wing S. Cheung、Ioanna P. Petrounia、Robert R. Donatelli、Margery A. Chaikin、Mark R. Player

  DOI：10.1016/j.bmcl.2007.09.057

  日期：2007.11

  A series of 2 '-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 mu M) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 mu M) and as such, serves as a lead candidate for further optimization studies. (C) 2007 Elsevier Ltd. All rights reserved.