13-Methyl-N-(propan-2-yl)-3,6,9-trioxa-12-azatetradecan-1-amine | 124477-32-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 13-Methyl-N-(propan-2-yl)-3,6,9-trioxa-12-azatetradecan-1-amine
• 英文别名: N-[2-[2-[2-[2-(propan-2-ylamino)ethoxy]ethoxy]ethoxy]ethyl]propan-2-amine
• CAS: 124477-32-3
• 化学式: C₁₄H₃₂N₂O₃
• 分子量: 276.42
• InChiKey: XSOAXXACLJTBDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] MDM2 DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION DE MDM2 ET LEURS UTILISATIONS
  申请人：KYMERA THERAPEUTICS INC

  公开号：WO2021188948A1

  公开（公告）日：2021-09-23

  The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

  本发明涉及化合物和方法，通过本发明的化合物对小鼠双分子2同源蛋白（"MDM2"）蛋白进行泛素化和/或降解的调节。
• Acid gas enrichment method and system
  申请人：BASF SE

  公开号：US10875769B2

  公开（公告）日：2020-12-29

  A process for treating an H2S- and CO2-comprising fluid stream, in which a) the fluid stream is treated in a first absorber at a pressure of 10 to 150 bar with a first substream of a regenerated H2S-selective absorbent to obtain a treated fluid stream and an H2S-laden absorbent; b) the H2S-laden absorbent is heated by indirect heat exchange with regenerated H2S-selective absorbent; c) the heated H2S-laden absorbent is decompressed to a pressure of 1.2 to 10 bar in a low-pressure decompression vessel to obtain a first CO2-rich offgas and a partly regenerated absorbent; d) the partly regenerated absorbent is regenerated in a desorption column to obtain an H2S-rich offgas and regenerated absorbent; e) the H2S-rich offgas is fed to a Claus unit and the offgas from the Claus unit is fed to a hydrogenation unit to obtain hydrogenated Claus tail gas; f) the hydrogenated Claus tail gas and the first CO2-rich offgas are treated in a second absorber at a pressure of 1 to 4 bar with a second substream of the regenerated H2S-selective absorbent to obtain a second CO2-rich offgas and a second H2S-laden absorbent; and g) the second H2S-laden absorbent is guided into the first absorber. Also described is a plant suitable for performance of the process. The process is notable for a low energy requirement.

  一种处理含有 H2S 和 CO2 的流体流的工艺，其中 a) 在压力为 10 至 150 巴的第一吸收器中，用再生的 选择性吸收剂的第一子流处理流体流，得到处理过的流体流和含有 的吸收剂；b) 通过与再生的 选择性吸收剂进行间接热交换，加热含有 的吸收剂；c) 在低压减压容器中，将加热的含有 的吸收剂减压至压力为 1.2至10巴的低压减压容器中减压，得到富含 的第一种尾气和部分再生的吸收剂；d) 部分再生的吸收剂在解吸塔中再生，得到富含 的尾气和再生的吸收剂；e) 将富含 的尾气送入克劳斯装置，将克劳斯装置的尾气送入加氢装置，得到加氢克劳斯尾气；f) 将氢化克劳斯尾气和第一种富含 的尾气在压力为 1 至 4 巴的第二吸收器中用再生 选择性吸收剂的第二子流进行处理，以获得第二种富含 的尾气和第二种富含 的吸收剂；以及 g) 将第二种富含 的吸收剂导入第一吸收器。此外，还介绍了适用于该工艺的设备。该工艺的显著特点是能耗低。
• ABSORPTIONSMITTEL UND VERFAHREN ZUR SELEKTIVEN ENTFERNUNG VON SCHWEFELWASSERSTOFF
  申请人：BASF SE

  公开号：EP3356014A1

  公开（公告）日：2018-08-08
• VERFAHREN UND ANLAGE ZUR SAUERGASANREICHERUNG
  申请人：BASF SE

  公开号：EP3386608A1

  公开（公告）日：2018-10-17
• CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20180162784A1

  公开（公告）日：2018-06-14

  Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.