2-[(Dichlorophosphoryl)oxy]-N,N,N-trimethylethan-1-aminium | 104254-68-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(Dichlorophosphoryl)oxy]-N,N,N-trimethylethan-1-aminium
• 英文别名: 2-dichlorophosphoryloxyethyl(trimethyl)azanium
• CAS: 104254-68-4
• 化学式: C5H13Cl2NO2P+
• 分子量: 221.04
• InChiKey: IKTQIZINHZVKJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Water-soluble L-DOPA esters
  申请人：BERLIREM GMBH

  公开号：US11046640B2

  公开（公告）日：2021-06-29

  The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.

  本发明涉及式 I 的新型化合物、其制备方法及其用于治疗疾病的用途。本发明公开了通过将多羟基化合物或其衍生物与 L-DOPA 羧基偶联合成左旋多巴（L-DOPA）酯。这种合成方法可以生产出高度溶于水以及水性和生物相容性液体的 L-DOPA 衍生物，并且在水或水性和生物相容性介质中具有更好的水解稳定性，可以应用数天。本发明有助于生产 L-DOPA 物质，应用于医学、生物学和医学工程领域以及制药业。
• Phosphoric acid esters, their preparation and their use for the preparation of biocompatible surfaces
  申请人：BIOCOMPATIBLES LTD.

  公开号：EP0157469B1

  公开（公告）日：1989-05-31
• WATER-SOLUBLE L-DOPA ESTERS
  申请人：Berlirem GmbH

  公开号：EP3277660A1

  公开（公告）日：2018-02-07
• POLYMER AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING INCLUDING THE POLYMER
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20170333575A1

  公开（公告）日：2017-11-23

  To provide a polymer having a high ratio of the amount thereof present in a tumor to the amount thereof present in blood (hereinafter, sometimes abbreviated as a tumor/blood ratio). The polymer has phosphorylcholine (derivative) as a side chain and has a dye (near-infrared dye) having absorption in the near-infrared wavelength region bound to the polymer.
• [EN] WATER-SOLUBLE L-DOPA ESTERS<br/>[FR] ESTERS DE L-DOPA SOLUBLES DANS L'EAU
  申请人：BERLIREM GMBH

  公开号：WO2016155888A1

  公开（公告）日：2016-10-06

  The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.