3-氨基丙基二异丙基乙氧基硅烷 | 117559-36-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 3-氨基丙基二异丙基乙氧基硅烷
• 英文名称: 3-[ethoxybis(1-methylethyl)silyl]propanamine
• 英文别名: 3-aminopropyldiisopropylethoxysilane；3-(ethoxy-diisopropyl-silanyl)-propylamine；3-(ethoxydiisopropylsilanyl)propylamine；3-[ethoxy-di(propan-2-yl)silyl]propan-1-amine
• CAS: 117559-36-1
• 化学式: C₁₁H₂₇NOSi
• 分子量: 217.427
• InChiKey: FSMHYZUFHYGNHS-UHFFFAOYSA-N

物化性质

• 熔点：
  >0°C
• 沸点：
  78-80°C 0,4mm
• 密度：
  0,87 g/cm3
• 闪点：
  >100°C

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• TSCA：
  No
• 储存条件：
  2-8°C，应密封存放在干燥处。

反应信息

• 作为反应物：
  描述：

  3-氨基丙基二异丙基乙氧基硅烷 在 copper(l) iodide 、 [n-DDTMA+][18F]F- 、 sodium ascorbate 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 溶剂黄146 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.58h， 生成
  参考文献：
  名称：

  Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups

  摘要：

  Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepared in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-Gly) either through a classical amide bond formation or through "click chemistry" via the Huisgen cycloaddition. The radiolabelling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54% decay corrected radiochemical yields. Radiolabelled peptides were easily prepared by direct F-18-fluorination of the silicon-bearing tripeptide or by coupling the peptide with a radiolabelled silicon-based prosthetic group. Their stabilities in physiological medium were studied and proved poor. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.01.011

文献信息

• Silicon-derivates for PET-Imaging
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1911452A1

  公开（公告）日：2008-04-16

  This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).

  本发明涉及适用于标记或已标记为18F的硅衍生化合物，制备这种化合物的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒以及这种化合物、组合物或试剂盒用于诊断成像，最好是正电子发射断层扫描（PET）的用途。
• Silicon derivatives for PET imaging
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1908472A1

  公开（公告）日：2008-04-09

  This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).

  本发明涉及适用于标记或已标记有18F的硅衍生化合物，制备这种化合物的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒以及这种化合物、组合物或试剂盒用于诊断成像，尤其是正电子发射断层扫描（PET）的用途。
• RADIOFLUORINATION
  申请人：Srinivasan Ananth

  公开号：US20090035215A1

  公开（公告）日：2009-02-05

  The present invention relates to novel compounds suitable for or already radiolabeled with 18 F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characerized by Formula II, wherein the moieties F, R 1 , R 2 , B 1,2 , Y 1,2 , Z 1,2 and E have the meaning as defined in the specification and claims.

  本发明涉及适用于或已标记为18F的新型化合物，制备这些化合物的方法以及将这些化合物用于诊断成像的方法。这些标记化合物的特点是公式II所示，其中F，R1，R2，B1，2，Y1，2，Z1，2和E的含义如规范和权利要求中所定义。
• Silicon-Based Building Blocks for One-Step18F-Radiolabeling of Peptides for PET Imaging
  作者：Linjing Mu、Aileen Höhne、P. August Schubiger、Simon M. Ametamey、Keith Graham、John E. Cyr、Ludger Dinkelborg、Timo Stellfeld、Ananth Srinivasan、Ulrike Voigtmann、Ulrich Klar

  DOI：10.1002/anie.200705854

  日期：2008.6.16
• Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups
  作者：Eva Balentova、Charlotte Collet、Sandrine Lamandé-Langle、Françoise Chrétien、David Thonon、Joël Aerts、Christian Lemaire、André Luxen、Yves Chapleur

  DOI：10.1016/j.jfluchem.2011.01.011

  日期：2011.4

  Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepared in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-Gly) either through a classical amide bond formation or through "click chemistry" via the Huisgen cycloaddition. The radiolabelling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54% decay corrected radiochemical yields. Radiolabelled peptides were easily prepared by direct F-18-fluorination of the silicon-bearing tripeptide or by coupling the peptide with a radiolabelled silicon-based prosthetic group. Their stabilities in physiological medium were studied and proved poor. (C) 2011 Elsevier B.V. All rights reserved.