5-Chloro-3-[(furan-2-yl)methyl]-1,3-benzoxazole-2(3H)-thione | 88882-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 5-Chloro-3-[(furan-2-yl)methyl]-1,3-benzoxazole-2(3H)-thione
• 英文别名: 5-chloro-3-(furan-2-ylmethyl)-1,3-benzoxazole-2-thione
• CAS: 88882-35-3
• 化学式: C₁₂H₈ClNO₂S
• 分子量: 265.72
• InChiKey: MCVRFIKDBBGESV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• MIF INHIBITORS
  申请人：JALCE Gael

  公开号：US20170029387A1

  公开（公告）日：2017-02-02

  Compounds of Formula (I′), and the use of the compounds of Formula (I′) as inhibitors of macrophage migration inhibitory factor (MIF). The use of compounds of Formula (I′) or pharmaceutical compositions thereof and method of using them, for treating disorders, diseases or conditions related to MIF.

  化合物的化学式（I′）及其作为巨噬细胞迁移抑制因子（MIF）抑制剂的用途。使用化合物的化学式（I′）或其药物组合物以及使用它们的方法，用于治疗与MIF相关的疾病、疾病或状况。
• MIF inhibitors
  申请人：Mifcare

  公开号：EP2929882A1

  公开（公告）日：2015-10-14

  The present invention relates to compounds of Formula I: The present invention relates to the use of the compounds of Formula I as inhibitors of macrophage migration inhibitory factor (MIF). The invention also relates to the use of compounds of Formula (I) or pharmaceutical compositions thereof and method using thereof, for treating disorders, diseases or conditions related to MIF.

  本发明涉及式 I 的化合物： 本发明涉及式Ⅰ化合物作为巨噬细胞迁移抑制因子（MIF）抑制剂的用途。本发明还涉及式（I）化合物或其药物组合物的用途及其使用方法，用于治疗与 MIF 有关的紊乱、疾病或病症。
• [EN] MIF INHIBITORS<br/>[FR] INHIBITEURS DE MIF
  申请人：MIFCARE

  公开号：WO2015155358A1

  公开（公告）日：2015-10-15

  The present invention relates to compounds of Formula (I'). The present invention relates to the use of the compounds of Formula (I') as inhibitors of macrophage migration inhibitory factor (MIF). The invention also relates to the use of compounds of Formula (I') or pharmaceutical compositions thereof and method using thereof, for treating disorders, diseases or conditions related to MIF.