8-nitro-4H-thieno[3,2-c]chromene | 1214261-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-nitro-4H-thieno[3,2-c]chromene
• CAS: 1214261-29-6
• 化学式: C₁₁H₇NO₃S
• 分子量: 233.247
• InChiKey: FPQCHNFVAHWRFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-[(2-Iodo-4-nitrophenoxy)methyl]thiophene 在 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以97%的产率得到8-nitro-4H-thieno[3,2-c]chromene
  参考文献：
  名称：

  Construction of Fused Thiophene Ring System via Intramolecular CH Arylation by Palladium Catalysis

  摘要：

  Intramolecular CH arylation of a thiophene derivative in the presence of a palladium catalyst furnishes fused tricyclic thiophene in a high yield. The obtained thiophene undergoes further intermolecular CH arylation with a palladium catalyst and AgNO3/KF.

  DOI：

  10.3987/com-09-s(s)10

文献信息

• 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
  申请人：BARBOSA Joseph

  公开号：US20120302562A1

  公开（公告）日：2012-11-29

  Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

  描述了可以用来抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物，以及它们用于治疗影响骨骼的疾病和紊乱的方法。
• US20140256784A1
  申请人：——

  公开号：US20140256784A1

  公开（公告）日：2014-09-11
• US9624238B2
  申请人：——

  公开号：US9624238B2

  公开（公告）日：2017-04-18
• [EN] 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE<br/>[FR] INHIBITEUR DE PECTINE ACÉTYLESTÉRASE DE NOTUM À BASE DE 4H-THIÉNO[3,2-C]CHROMÈNE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2012166458A1

  公开（公告）日：2012-12-06

  Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
• Construction of Fused Thiophene Ring System via Intramolecular CH Arylation by Palladium Catalysis
  作者：Atsunori Mori、Nobumichi Arai、Tomomi Hatta、Daiki Monguchi

  DOI：10.3987/com-09-s(s)10

  日期：——

  Intramolecular CH arylation of a thiophene derivative in the presence of a palladium catalyst furnishes fused tricyclic thiophene in a high yield. The obtained thiophene undergoes further intermolecular CH arylation with a palladium catalyst and AgNO3/KF.