N-[2-(3,4-Dihydroxyphenyl)ethyl]glycine | 97795-07-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[2-(3,4-Dihydroxyphenyl)ethyl]glycine
• 英文别名: 2-[2-(3,4-dihydroxyphenyl)ethylamino]acetic acid
• CAS: 97795-07-8
• 化学式: C₁₀H₁₃NO₄
• 分子量: 211.21
• InChiKey: LPICCNGZMXINAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Novel substrates for D-amino acid oxidase
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0146067A2

  公开（公告）日：1985-06-26

  This invention relates to substrates of D-amino acid oxidase which are valuable therapeutic agents. More particularly, the compounds of the present invention includes a D-amino acid oxidase substrate of the structural formula and the pharmaceutically acceptable salts thereof, wherein R is H, -CH3, -CH3CH2-, CH3CH2CH2-, CH3(CH2)2CH2-, (CH3) 2CH-, -CH20H, CH3CH2SCH2CH2-, CH3SCH2-, CH3SCH2CH2-, C6H5CH2-, 4-OH-C6H4 CH2-, 3,4-diOH-C6H3CH2- and and R1 is the des-amino residue of a -NH2 bearing therapeutic agent.

  本发明涉及作为有价值的治疗剂的 D-氨基酸氧化酶底物。更具体地说，本发明的化合物包括结构式如下的 D-氨基酸氧化酶底物及其药学上可接受的盐类 及其药学上可接受的盐，其中 R 是 H、-CH3、- -、 -、 (CH2)2 -、( ) 2CH-、 - 0H、 S -、 S -、 S -、C6H5 -、4-OH-C6H4 -、3,4-diOH-C6H3 -和 和 R1 是含有-NH2 的治疗剂的去氨基残基。
• Biological buffers with wide buffering ranges
  申请人：Daly Thomas

  公开号：US10927279B2

  公开（公告）日：2021-02-23

  Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

  胺和胺衍生物可改善缓冲范围，和/或减少缓冲剂与待缓冲体系之间的螯合作用和其他负作用。胺或多胺与各种分子反应生成具有不同 pKa 的多胺，可扩大缓冲范围，而生成具有相同 pKa 的多胺的衍生物可产生更大的缓冲能力。产生齐聚物缓冲剂的衍生物可通过扩大稳定性范围来提高产量。
• Biological Buffers with Wide Buffering Ranges
  申请人：Daly Thomas

  公开号：US20120316359A1

  公开（公告）日：2012-12-13

  Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
• NOVEL SUPERCOOLING METHODS FOR PRESERVATION OF BIOLOGICAL SAMPLES
  申请人：X-Therma, Inc.

  公开号：US20200170241A1

  公开（公告）日：2020-06-04

  The present invention provides methods for cryopreserving a population of cells with improved cell viability. In some aspects, the method comprises contacting a population of cells with a peptoid polymer comprising one or more polar peptoid monomers, e.g., formulated in a cryoprotectant solution, and cooling the population of cells at a temperature of from 0° C. to about −20° C. for a time period of at least about 3 hours to produce a population of supercooled cells. The supercooling methods of the present invention provide excellent post-thaw cell survival and recovery. In certain embodiments, the population of cells is present in a tissue or an organ that is cryopreserved by performing the supercooling methods of the present invention.
• NOVEL PEPTOID POLYMERS AND METHODS OF USE
  申请人：X-Therma, Inc.

  公开号：US20200239632A1

  公开（公告）日：2020-07-30

  The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.