5-(Chloromethyl)-2-methoxyphenol | 529502-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(Chloromethyl)-2-methoxyphenol
• CAS: 529502-39-4
• 化学式: C₈H₉ClO₂
• 分子量: 172.61
• InChiKey: LTUZKIDUBAFOGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR PRODUCING A HIGH-PURITY AROMATIC METHYL ALCOHOL AND HIGH-PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT PRESERVATION STABILITY
  申请人：Doi Takashi

  公开号：US20120323021A1

  公开（公告）日：2012-12-20

  An object of the present invention is to provide a high-purity aromatic methyl alcohol compound having reduced a bis(arylmethyl)ether compound as a side product mixed thereinto and a high-purity aromatic methyl alcohol composition having excellent preservation stability and methods for producing them. The object of the present invention is achieved by a method for producing a high-purity aromatic methyl alcohol compound, which comprises obtaining a high-purity aromatic methyl alcohol compound in high yield from an aromatic methyl alcohol-containing crude product by subjecting the crude product to distillation in the presence of an anti-decomposition agent. Further, the object for the preservation stability is achieved by producing a high-purity aromatic methyl alcohol composition using the obtained high-purity aromatic methyl alcohol compound.

  本发明的目的是提供一种高纯度芳香基甲醇化合物，其中混有减少的双(芳基甲基)醚化合物作为副产物，并且具有良好的保存稳定性的高纯度芳香基甲醇组合物及其生产方法。本发明的目的通过以下方法实现：通过在抗分解剂的存在下对含芳香基甲醇的原始产品进行蒸馏，从而高产率地获得高纯度芳香基甲醇化合物。此外，通过使用获得的高纯度芳香基甲醇化合物生产高纯度芳香基甲醇组合物，实现了保存稳定性的目标。
• METHOD FOR PRODUCING HIGH PURITY AROMATIC METHYL ALCOHOL, AND HIGH PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT STORAGE STABILITY
  申请人：Ube Industries, Ltd.

  公开号：EP2540695A1

  公开（公告）日：2013-01-02

  An object of the present invention is to provide a high-purity aromatic methyl alcohol compound having reduced a bis(arylmethyl) ether compound as a side product mixed thereinto and a high-purity aromatic methyl alcohol composition having excellent preservation stability and methods for producing them. The object of the present invention is achieved by a method for producing a high-purity aromatic methyl alcohol compound, which comprises obtaining a high-purity aromatic methyl alcohol compound in high yield from an aromatic methyl alcohol-containing crude product by subjecting the crude product to distillation in the presence of an anti-decomposition agent. Further, the object for the preservation stability is achieved by producing a high-purity aromatic methyl alcohol composition using the obtained high-purity aromatic methyl alcohol compound.

  本发明的目的是提供一种高纯度芳香族甲醇化合物，其中混有作为副产物的还原双(芳基甲基)醚化合物，以及一种具有优异保存稳定性的高纯度芳香族甲醇组合物及其生产方法。 本发明的目的是通过一种生产高纯度芳香族甲醇化合物的方法来实现的，该方法包括在有抗分解剂存在的情况下，通过对含芳香族甲醇的粗产品进行蒸馏，以高产率从该粗产品中获得高纯度芳香族甲醇化合物。此外，通过使用所获得的高纯度芳香族甲醇化合物生产高纯度芳香族甲醇组合物，还可实现防腐稳定性的目标。
• [EN] COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY<br/>[FR] COMPOSES AYANT UNE ACTION CONTRE L'HELICOBACTER PYLORI
  申请人：ASTRAZENECA AB

  公开号：WO2001034578A1

  公开（公告）日：2001-05-17

  The invention relates to compounds of formula (I) which have anti-Helicobacter pylori activity.
• [EN] PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT DE MALADIES À MÉDIATION ASSURÉE PAR LE CFTR
  申请人：VERTEX PHARMA

  公开号：WO2015073231A1

  公开（公告）日：2015-05-21

  Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.