5-bromo-N,N-bis(methoxymethyl)pyridin-2-amine | 1443451-93-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-bromo-N,N-bis(methoxymethyl)pyridin-2-amine
• CAS: 1443451-93-1
• 化学式: C₉H₁₃BrN₂O₂
• 分子量: 261.118
• InChiKey: RNSYTPIPQODEAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-丙二硫醇 、 5-bromo-N,N-bis(methoxymethyl)pyridin-2-amine 在 copper dichloride 作用下， 以 氯仿 为溶剂， 反应 2.5h， 以64%的产率得到3-(5-bromopyridin-2-yl)-1,5,3-dithiazocane
  参考文献：
  名称：

  Synthesis of 3-hetaryl-1,5,3-dithiazepanes and 3-hetaryl-1,5,3-dithiazocanes in the presence of catalysts based on transition metals

  摘要：

  Efficient procedure was developed for 3-hetaryl-1,5,3-dithiazepanes and 3-hetaryl-1,5,3-dithiazocanes preparation from hetarylamines, N,N,N',N'-tetramethylmethanediamine, and alpha,omega-alkanedithiols (ethane-1,2-dithiol, propane-1,3-dithiol), and also by the reaction of the latter with N,N-bis(methoxymethyl)hetarylamines in the presence of catalytic quantities of transition metals salts.

  DOI：

  10.1134/s1070428013050035

文献信息

• Synthesis of 3-hetaryl-1,5,3-dithiazepanes and 3-hetaryl-1,5,3-dithiazocanes in the presence of catalysts based on transition metals
  作者：N. N. Makhmudiyarova、K. I. Prokof’ev、L. V. Mudarisova、A. G. Ibragimov、U. M. Dzhemilev

  DOI：10.1134/s1070428013050035

  日期：2013.5

  Efficient procedure was developed for 3-hetaryl-1,5,3-dithiazepanes and 3-hetaryl-1,5,3-dithiazocanes preparation from hetarylamines, N,N,N',N'-tetramethylmethanediamine, and alpha,omega-alkanedithiols (ethane-1,2-dithiol, propane-1,3-dithiol), and also by the reaction of the latter with N,N-bis(methoxymethyl)hetarylamines in the presence of catalytic quantities of transition metals salts.