1-(Aminomethyl)cyclohexane-1-carbonitrile | 1513267-68-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(Aminomethyl)cyclohexane-1-carbonitrile
• CAS: 1513267-68-9
• 化学式: C₈H₁₄N₂
• 分子量: 138.21
• InChiKey: ZFXSRXFFVQUSJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING PLANT DISEASES
  申请人：Komori Takashi

  公开号：US20100105647A1

  公开（公告）日：2010-04-29

  Disclosed is an amide compound represented by the following formula (1). (1) (In the formula, X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A 1 -CR 6 R 7 R 8 group, an A 2 -Cy 1 group or an A 3 -Cy 2 group, wherein A 1 represents a CH 2 group or the like, A 2 represents a single bond, a CH 2 group or the like, Cy 1 represents a C 3 -C 6 cycloalkyl group substituted with a C 1 -C 6 alkoxy group or the like, Cy 2 represents a C 3 -C 6 cycloalkyl group which may be substituted with at least one halogen atom or the like, R 6 and R 7 independently represent a C 1 -C 4 alkyl group, and R 8 represents a halogen atom, a hydroxyl group or the like.) The amide compound has excellent plant disease controlling activity.

  本发明涉及一种由以下式（1）表示的酰胺化合物。（1）（在该式中，X1表示氟原子或甲氧基；X2表示氢原子，卤素原子，C1-C4烷基或类似物；Z表示氧原子或硫原子；A表示A1-CR6R7R8基团，A2-Cy1基团或A3-Cy2基团，其中A1表示CH2基团或类似物，A2表示单键， 基团或类似物，Cy1表示C3-C6环烷基取代的C1-C6烷氧基或类似物，Cy2表示C3-C6环烷基，可以用至少一个卤素原子或类似物取代，R6和R7独立地表示C1-C4烷基，R8表示卤素原子，羟基或类似物。）该酰胺化合物具有出色的植物病害控制活性。
• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150344425A1

  公开（公告）日：2015-12-03

  The invention relates to indole carboxamide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  该发明涉及式(I)的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和n如描述中所定义，它们的制备以及它们作为药物活性化合物的用途。
• P2X7 receptor antagonists for restoring T-cell lymphopoiesis in subjects infected with human immunodeficiency virus (HIV)
  申请人：INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

  公开号：US10548980B2

  公开（公告）日：2020-02-04

  The present invention relates to pharmaceutical composition and uses thereof for restoring T-cell lymphopoiesis in subjects infected with human immunodeficiency virus (HIV). In particular, the present invention relates to a P2X7 receptor antagonist for use in a method of restoring T-cell lymphopoiesis in a subject infected with human immunodeficiency virus (HIV) comprising administering to the subject a therapeutically effective amount of said P2X7 receptor antagonist.

  本发明涉及用于恢复感染人类免疫缺陷病毒（HIV）的受试者的T细胞淋巴细胞生成的药物组合物及其用途。特别是，本发明涉及一种P2X7受体拮抗剂，用于在感染了人类免疫缺陷病毒（HIV）的受试者中恢复T细胞淋巴细胞生成的方法，该方法包括向受试者施用治疗有效量的所述P2X7受体拮抗剂。
• P2X7 RECEPTOR ANTAGONISTS FOR RESTORING T-CELL LYMPHOPOIESIS IN SUBJECTS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV)
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP3402469B1

  公开（公告）日：2021-01-06
• US8003699B2
  申请人：——

  公开号：US8003699B2

  公开（公告）日：2011-08-23