N-3-hydroxypropyl-N-propylmethylamine | 27453-40-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-3-hydroxypropyl-N-propylmethylamine
• 英文别名: 3-(Methyl-propyl-amino)-propanol；methylpropylaminopropyl alcohol；3-[Methyl(propyl)amino]propan-1-ol
• CAS: 27453-40-3
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: HYZSAVPHAAUKMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] CHEMICAL COMPOUNDS<br/>[FR] DERIVES DE QUINAZOLINE POUR LE TRAITEMENT DU CANCER
  申请人：ASTRAZENECA AB

  公开号：WO2004094410A1

  公开（公告）日：2004-11-04

  Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing them as active ingredient.

  公式（I）的喹唑啉衍生物；用于治疗癌症等增殖性疾病，并用于制备用于治疗增殖性疾病的药物，以及它们的制备方法，以及含有它们作为活性成分的药物组合物。
• [EN] AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS<br/>[FR] INDOLS AMINOALKOXY UTILISES EN TANT QUE LIGANDS DU RECEPTEUR 5-HT6 POUR LE TRAITEMENT DE TROUBLES DU SNC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004050085A1

  公开（公告）日：2004-06-17

  The invention provides compound of the Formula (I) and pharmaceutically acceptable salts wherein R1, R2, R3, R4, m and n are as defined herein. The invention also provides methods for preparing, compositions comprising, and the use of compounds of formula (I) for the manufacture of a medicament for the treatment of 5-HT6 mediated diseases.

  该发明提供了化合物的公式（I）及其药用盐，其中R1、R2、R3、R4、m和n如本文所定义。该发明还提供了制备方法、包含的组合物以及利用公式（I）化合物制造用于治疗5-HT6介导疾病的药物的用途。
• N5-substituted benzo¬2,3|azepino¬4,5-b|indol-6-ones for treating tropical diseases
  申请人：Molisa GmbH

  公开号：EP1757607A1

  公开（公告）日：2007-02-28

  The present invention relates to novel N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones of the general formula (1): and pharmaceutically acceptable salts thereof, the use of these compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of South American trypanosomiasis, African trypanosomiasis, sleeping sickness, Kala-Azar, visceral leishmaniasis, Baghdad boil or Aleppo boil, cutaneous leishmaniasis (CL), espundia, Chagas disease, mucocutaneous leishmaniasis (MCL), trichomoniasis, urogenital trichomonosis, giardiasis, lamblia dysentery, amoebiasis, primary amebic meningoencephalitis (PAM), keratitis or meningitis, coccidiosis, sarcosporidosis, toxoplasmosis, Malaria tropica, Malaria tertiana, Malaria quartana, pneumocystis carinii, pneumonia, pneumocystosis, Balantidium dysentery, and oriental sore. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones and/or pharmaceutically acceptable salts thereof.

  本发明涉及一种新型的N5-取代苯并[2,3]哌啶[4,5-b]吲哚-6-酮，其通式为(1)，以及其药学上可接受的盐，这些化合物作为药物活性剂的用途，特别用于南美锥虫病、非洲锥虫病、睡眠病、卡拉阿扎尔病、内脏利什曼病、巴格达疖或阿勒颇疖、皮肤利什曼病（CL）、恩普迪亚、查加斯病、粘膜皮肤利什曼病（MCL）、滴虫病、泌尿生殖道滴虫病、贾第虫病、贾第虫病性痢疾、阿米巴病、原发性阿米巴脑膜脑炎（PAM）、角膜炎或脑膜炎、球虫病、肉囊虫病、弓形虫病、疟疾疟疾、三日疟、四日疟、肺孢子虫肺炎、肺孢子虫病、巴兰蒂迪痢疾和东方疮的预防和/或治疗。此外，本发明还涉及含有至少一种N5-取代苯并[2,3]哌啶[4,5-b]吲哚-6-酮和/或其药学上可接受的盐的药物组合物。
• [EN] CHINAZOLINE DERIVATIVES AS AURORA KINASE INHIBITORS<br/>[FR] DERIVES DE QUINAZOLINE TENANT LIEU D'INHIBITEURS DE L'AURORA KINASE
  申请人：ASTRAZENECA AB

  公开号：WO2004113324A1

  公开（公告）日：2004-12-29

  Quinazoline derivatives of formula (I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) formula (I) for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing them as active ingredient.

  化学式（I）的喹唑啉衍生物用于治疗增生性疾病，如癌症，并用于制备用于治疗增生性疾病的药物，以及用于其制备的方法，以及含有它们作为活性成分的药物组合物。
• PREPARATION OF N,N-(DI)ALKYLAMINOALKYL(METH)ACRYLAMIDE OR N,N-(DI)ALKYLAMINOALKYL (METH)ACRYLATE AND THE QUATERNARY AMMONIUM SALTS THEREOF AS FLOCCULATING AIDS AND GELLING AGENTS
  申请人：Evonik Roehm GmbH

  公开号：US20170369424A1

  公开（公告）日：2017-12-28

  N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R 5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.

  制备低含量的化合物公式（IV）其中R5在每种情况下都是线性，支链或环烷基，芳基，也可以被一个或多个烷基取代，线性，环状或支链烷基长度可以为1-12个碳原子，例如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基，戊基，己基，庚基，异辛基，壬基，癸基。制备N，N-（二）烷基氨基烷基（甲基）丙烯酰胺或N，N-（二）烷基氨基烷基（甲基）丙烯酸酯和/或其季铵盐。