4-Hydrazinomethyl-2-methoxy-phenol | 90197-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Hydrazinomethyl-2-methoxy-phenol
• 英文别名: 4-(Hydrazinylmethyl)-2-methoxyphenol
• CAS: 90197-32-3
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: XWMXPYRNKXRHAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] EFFICIENT SYNTHESIS OF AMINES AND AMIDES FROM ALCOHOLS AND ALDEHYDES BY USING CASCADE CATALYSIS<br/>[FR] SYNTHÈSE EFFICACE D'AMINES ET D'AMIDES À PARTIR D'ALCOOLS ET D'ALDÉHYDES PAR CATALYSE EN CASCADE
  申请人：CÓRDOVA ARMANDO

  公开号：WO2015144902A1

  公开（公告）日：2015-10-01

  The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal-and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

  本发明一般涉及一种环保的方法，用于将醇和醛转化为胺和酰胺，采用集成的酶级联系统与金属和有机催化。更具体地，本发明涉及从香草醛醇开始合成辣椒素类化合物，使用酶级联系统和催化剂的组合。此外，该方法还涉及从香草醛醇衍生物开始合成辣椒素类化合物衍生物，使用酶级联系统和催化剂的组合。
• Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
  申请人：XP Chemistries AB

  公开号：US11168050B2

  公开（公告）日：2021-11-09

  The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

  本发明总体上涉及一种利用金属和有机催化的集成酶级联系统将醇和醛转化为胺和酰胺的环保方法。更具体地说，本发明涉及以香兰素醇为起点，结合酶级联系统和催化剂合成辣椒素。此外，该方法还涉及从香兰素醇衍生物开始，利用酶级联系统和催化剂的组合合成辣椒素衍生物。
• Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer
  申请人：——

  公开号：US20030072821A1

  公开（公告）日：2003-04-17

  The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of catechins and vanilloids. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). In a preferred embodiment the catechins have been treated with tannase. Compositions of vanilloids include, but are not limited to vanillylamine, the head group of capsaicin. The unique compositions of the invention contain various combinations of the catechins and vanilloids, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses various modes of administration of the therapeutic compounds, including formulations which may be used as a dietary or nutritional supplement or as a therapeutic compound.

  本发明包括预防或治疗癌症的方法和组合物，其中包括儿茶素和类香兰素的组合用药。儿茶素成分包括但不限于表没食子儿茶素没食子酸酯（EGCg）、表儿茶素（EC）、表儿茶素没食子酸酯（ECG）、表没食子儿茶素（EGC）。在一个优选的实施方案中，儿茶素已用单宁酸酶处理过。香草素成分包括但不限于辣椒素的头基香草胺。本发明的独特组合物包含儿茶素和香草素的各种组合，相互结合或与其他治疗剂结合，可用于治疗人类的原发性和转移性癌症。本发明还包括治疗化合物的各种给药方式，包括可用作膳食或营养补充剂或治疗化合物的制剂。
• Treatment for bacterial infections and related disorders
  申请人：Staggs J. Jeff

  公开号：US20050058729A1

  公开（公告）日：2005-03-17

  A novel treatment for bacterial infections and related disorders derived from extracts of pepper, ginger, and related plant species containing vanillyl (FIG. 3 ), and piperidine (FIG. 7 ) ring structures typical of the pungent principals found in pepper, and ginger. The pepper extracts, which also possess antifungal properties are demonstrated in the topical treatment of bacterial infections affecting the skin eyes, and ears.

  一种治疗细菌感染及相关疾病的新型疗法，提取自含有香草醛（图 3）的胡椒、生姜及相关植物物种的提取物。 3 )和哌啶（图 7 7 的环状结构，是胡椒和生姜中典型的辛辣成分。胡椒提取物还具有抗真菌特性，可用于局部治疗影响皮肤、眼睛和耳朵的细菌感染。
• EFFICIENT SYNTHESIS OF AMINES AND AMIDES FROM ALCOHOLS AND ALDEHYDES BY USING CASCADE CATALYSIS
  申请人：Organofuel Sweden AB

  公开号：EP3122715B1

  公开（公告）日：2019-05-01