((5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-4-cyclopentyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]methanone | 893407-74-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-4-cyclopentyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]methanone
• 英文别名: [(5S)-5-[tert-butyl(dimethyl)silyl]oxy-4-cyclopentyl-7,7-dimethyl-2-propan-2-yl-6,8-dihydro-5H-quinolin-3-yl]-[4-(trifluoromethyl)phenyl]methanone
• CAS: 893407-74-4
• 化学式: C₃₃H₄₆F₃NO₂Si
• 分子量: 573.814
• InChiKey: OPHQYCXZXJUWOK-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.15
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ((5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-4-cyclopentyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]methanone 在 lithium aluminium tetrahydride 、 水 、 Rochelle's salt 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 (RS)-((5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-4-cyclopentyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetra-hydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]methanol
  参考文献：
  名称：

  WO2006/63828

  摘要：

  公开号：
• 作为产物：
  描述：

  [(5S)-4-cyclopentyl-5-hydroxy-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl][4-(trifluoromethyl)phenyl]methanone 、 叔丁基二甲硅基三氟甲磺酸酯 在 2,6-二甲基吡啶 作用下， 以 甲苯 为溶剂， 反应 1.25h， 以100%的产率得到((5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-4-cyclopentyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]methanone
  参考文献：
  名称：

  WO2006/63828

  摘要：

  公开号：

文献信息

• Chemical Compound and Its Use
  申请人：Bischoff Hilmar

  公开号：US20080255068A1

  公开（公告）日：2008-10-16

  The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

  本申请涉及一种新型四氢喹啉衍生物，其制备方法，其在单独使用或联合使用时用于治疗和/或预防疾病的用途，以及其用于制备药物的用途，特别是作为胆固醇酯转移蛋白（CETP）抑制剂，用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，脂质代谢异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。
• CHEMICAL COMPOUND AND ITS USE
  申请人：BISCHOFF Hilmar

  公开号：US20120142728A1

  公开（公告）日：2012-06-07

  The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

  本申请涉及一种新型四氢喹啉衍生物，其制备方法，其单独或联合用于治疗和/或预防疾病以及其用于制备药物，特别是作为胆固醇酯转移蛋白（CETP）的抑制剂，用于治疗和/或预防心血管疾病，特别是低脂蛋白血症、脂质代谢异常、高三酰甘油血症、高脂血症、高胆固醇血症和动脉硬化。
• Chemical compound and its use
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US08124775B2

  公开（公告）日：2012-02-28

  The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

  本申请涉及一种新型四氢喹啉衍生物，其制备方法，其单独或与其他药物联合治疗和/或预防疾病的用途以及其用于制备药物，特别是作为胆固醇酯转移蛋白（CETP）的抑制剂，用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，脂质代谢异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。