(2-{3-bromo-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate | 689259-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2-{3-bromo-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetic acid trifluoroacetate
• 英文别名: 2-[2-[3-Bromo-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl]cyclopropyl]acetic acid;2,2,2-trifluoroacetic acid
• CAS: 689259-90-3
• 化学式: C₂HF₃O₂*C₂₁H₂₃BrN₂O₃
• 分子量: 545.353
• InChiKey: DROZAXBWYHXDIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.04
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
  申请人：——

  公开号：US20040092538A1

  公开（公告）日：2004-05-13

  The present invention relates to a class of compounds represented by the Formula I 1 or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr; v &bgr; 3 and/or &agr; v &bgr; 5 integrin.

  本发明涉及一类由公式I代表的化合物 1 或其药用可接受的盐，包含公式I化合物的药物组合物，以及选择性地抑制或拮抗α v β 3 和/或α v β 5 整合素的方法。
• STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1499286A1

  公开（公告）日：2005-01-26
• US6921767B2
  申请人：——

  公开号：US6921767B2

  公开（公告）日：2005-07-26
• [EN] STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS<br/>[FR] PRODUITS POUR SOINS CORPORELS STABILISES, PRODUITS MENAGERS, TEXTILES ET TISSUS
  申请人：CIBA SC HOLDING AG

  公开号：WO2003103622A1

  公开（公告）日：2003-12-18

  Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.