5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride | 210297-47-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride
• 英文别名: 5-piperazin-1-ylsulfonylisoquinoline;dihydrochloride
• CAS: 210297-47-5
• 化学式: C13H17Cl2N3O2S
• mdl: MFCD01310980
• 分子量: 350.3
• InChiKey: ZKQAPKKKTQCVKG-UHFFFAOYSA-N

物化性质

• 溶解度：
  不溶于乙醇；水中≥131.8 mg/mL；超声波检测下 DMSO 中≥19.17 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  0.26
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  70.7
• 氢给体数：
  3
• 氢受体数：
  5

制备方法与用途

生物活性

HA-100 dihydrochloride 是 cGMP-dependent protein kinase (PKG)、cAMP-dependent protein kinase (PKA)、protein kinase C (PKC) 和 MLC-kinase 的抑制剂，对应的IC50值分别为4 μM、8 μM、12 μM和240 μM。

靶点

Target	Value
PKG (Cell-free assay)	4 μM
PKA (Cell-free assay)	8 μM
PKC (Cell-free assay)	12 μM
MLCK (Cell-free assay)	240 μM

文献信息

• Use of standards for monitoring alterations of peptide and protein samples
  申请人：BioVisioN AG

  公开号：EP1619503A1

  公开（公告）日：2006-01-25

  The present invention is directed to methods of using standards for determining and monitoring alterations and variations of peptide and protein samples. More specifically, the present invention relates to methods of determining and monitoring alterations of the sample quality, in particular after collection, during processing and during storage of the sample.

  本发明涉及使用标准品确定和监测肽和蛋白质样品的变化和变异的方法。更具体地说，本发明涉及确定和监测样品质量变化的方法，特别是在样品采集后、处理过程中和储存期间。
• USE OF STANDARDS FOR MONITORING ALTERATIONS OF PEPTIDE AND PROTEIN SAMPLES
  申请人：DIGILAB BioVisioN GmbH

  公开号：EP1766416A1

  公开（公告）日：2007-03-28
• [EN] USE OF STANDARDS FOR MONITORING ALTERATIONS OF PEPTIDE AND PROTEIN SAMPLES<br/>[FR] APPLICATION DE NORMES POUR CONTROLER DES ALTERATIONS D'ECHANTILLONS DE PEPTIDES ET DE PROTEINES
  申请人：BIOVISION AG

  公开号：WO2006005622A1

  公开（公告）日：2006-01-19

  The present invention is directed to methods of using standards for determining and monitoring alterations and variations of peptide and protein samples. More specifically, the present invention relates to methods of determining and monitoring alterations of the sample quality, in particular after collection, during processing and during storage of the sample.