(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;(5S)-1-methyl-5-pyridin-1-ium-3-ylpyrrolidine-2-selone | 1565854-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;(5S)-1-methyl-5-pyridin-1-ium-3-ylpyrrolidine-2-selone
• CAS: 1565854-18-3
• 化学式: C₁₀H₁₂N₂Se*C₂₄H₄₀O₃
• 分子量: 615.758
• InChiKey: GCZWDVILRUQRJG-RBCUVDQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.65
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  73.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-1-methyl-5-(3-pyridil)pyrrolidin-2-selenone 、 石胆酸 以 甲醇 为溶剂， 反应 12.0h， 以88%的产率得到(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;(5S)-1-methyl-5-pyridin-1-ium-3-ylpyrrolidine-2-selone
  参考文献：
  名称：

  Synthesis and haemolytic activity of novel salts made of nicotine alkaloids and bile acids

  摘要：

  A series of novel salts made of nicotine alkaloids and bile acids were synthesized and their haemolytic activity was examined in vitro using human erythrocytes. All compounds were characterized by spectroscopic methods. The novel salts show membrane-perturbing properties inducing the erythrocyte shape alterations and haemolysis in dose-dependent manner. Nicotine decreases the membrane interacting potential of bile acids in the novel compounds. The presence of sulfur or selenium atom in the nicotine molecule affects the haemolytic activity of its novel salts depending on the hydrophobicity of bile acids. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.005