(Z)-5-(2-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol | 1246764-53-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-5-(2-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
• 英文别名: 5-[(Z)-2-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethenyl]-2-methoxyphenol
• CAS: 1246764-53-3
• 化学式: C₂₅H₂₆O₇
• 分子量: 438.477
• InChiKey: QPJBHPVDTAMJIR-ZDLGFXPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (Z)-1-(1,2-bis(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-2-bromo-3,4,5-trimethoxybenzene 在 正丁基锂 、 盐酸 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以97%的产率得到(Z)-5-(2-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
  参考文献：
  名称：

  Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

  摘要：

  A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.007

文献信息

• Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4
  作者：Evelia Rasolofonjatovo、Olivier Provot、Abdallah Hamze、Jérome Bignon、Sylviane Thoret、Jean-Daniel Brion、Mouâd Alami

  DOI：10.1016/j.ejmech.2010.05.007

  日期：2010.9

  A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.