AZD-7325 hydrogen sulfate | 1252802-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: AZD-7325 hydrogen sulfate
• 英文别名: 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide;sulfuric acid
• CAS: 1252802-75-7
• 化学式: C19H21FN4O6S
• 分子量: 452.5
• InChiKey: BPPOEEBZBHFARK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.51
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] PHARMACEUTICAL COMPOSITION COMPRISING 4-AMINO-8-(2-FLUORO-6-METHOXY-PHENYL)-N- PROPYLCINNOLINE-3-CARBOXAMIDE HYDROGEN SULPHATE AND RATE-CONTROLLING POLYMER<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT DE L'HYDROGÉNOSULFATE DE 4-AMINO-8-(2-FLUORO-6-MÉTHOXY-PHÉNYL)-N-PROPYLCINNOLINE-3-CARBOXAMIDE ET POLYMÈRE DE RÉGULATION DE LA VITESSE
  申请人：ASTRAZENECA AB

  公开号：WO2010123440A1

  公开（公告）日：2010-10-28

  Disclosed is a pharmaceutical composition for extended release of a cinnoline derivative in the gastrointestinal environment. The composition comprises an cinnoline derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically lower Cmax in the plasma than an immediate release composition of the cinnoline derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the cinnoline derivative upon multiple dosing. The compositions of the invention have reduced side effects as compared to those for the immediate release composition.
• [EN] PHARMACEUTICAL COMPOSITION COMPRISING 4-AMINO-8-(2-FLUORO-6-METHOXY-PHENYL)-N- PROPYLCINNOLINE-3-CARBOXAMIDE HYDROGEN SULPHATE.<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT DE L'HYDROGÉNOSULFATE DE 4-AMINO-8-(2-FLUORO-6-MÉTHOXY-PHÉNYL)-N-PROPYLCINNOLINE-3-CARBOXAMIDE
  申请人：ASTRAZENECA AB

  公开号：WO2010123443A1

  公开（公告）日：2010-10-28

  Disclosed is a pharmaceutical composition for a cinnoline derivative in the gastrointestinal environment. The composition comprising a solid cinnoline derivative and at least one pharmaceutical excipient selected from a filler, a binder, a disintegrant, a suspending agent, a coating agent, a sweetener, a flavoring, and a lubricant.
• [EN] CRYSTALLINE FORM OF 4-AMINO-8-(2-FLUORO-6-METHOXY-PHENYL)-N-PROPYLCINNOLINE-3- CARBOXAMIDE HYDROGEN SULPHATE, FOR TREATMENT OF ANXIETY DISORDERS<br/>[FR] FORME CRISTALLINE DE L'HYDROGÉNOSULFATE DE 4-AMINO-8-(2-FLUORO-6-MÉTHOXY-PHÉNYL)-N-PROPYLCINNOLINE-3-CARBOXAMIDE POUR LE TRAITEMENT DE TROUBLES LIÉS À L'ANXIÉTÉ
  申请人：ASTRAZENECA AB

  公开号：WO2010123441A1

  公开（公告）日：2010-10-28

  4-Amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide hydrogen sulphate, polymorphs thereof, pharmaceutical compositions contain them, methods of making them are described. They are useful in treating anxiety disorders.