4-Ethyl-4-methylchromeno[4,3-d]thiadiazole | 1246537-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4-Ethyl-4-methylchromeno[4,3-d]thiadiazole
• CAS: 1246537-78-9
• 化学式: C₁₂H₁₂N₂OS
• 分子量: 232.306
• InChiKey: RAUFQMFGSASANW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [(2-ethyl-2-methyl-3H-chromen-4-ylidene)amino]urea 在 氯化亚砜 作用下， 反应 0.17h， 以97%的产率得到4-Ethyl-4-methylchromeno[4,3-d]thiadiazole
  参考文献：
  名称：

  Synthesis and Biological Screening of Novel Thiadiazoles, Selenadiazoles, and Spirocyclic Benzopyran by Ultrasonic and Microwave Irradiation

  摘要：

  We describe the synthesis of novel thiadiazole, selenadiazole, and spirocyclic benzopyrans via the semicarbazides 3 and thiosemicarbazides 3 of 2-ethyl-2-methyl-4H-chromen-4-ones 1 by conventional and nonconventional methods. The microwave and ultrasonic irradiation methods form the respective products in excellent yields in very short reaction time as compared to the conventional method. The synthesized compounds were tested for antimicrobial screening against bacteria and fungi show moderate activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500903136913

文献信息

• Synthesis and Biological Screening of Novel Thiadiazoles, Selenadiazoles, and Spirocyclic Benzopyran by Ultrasonic and Microwave Irradiation
  作者：A. D. Shinde、S. S. Sonar、B. B. Shingate、M. S. Shingare

  DOI：10.1080/10426500903136913

  日期：2010.7.30

  We describe the synthesis of novel thiadiazole, selenadiazole, and spirocyclic benzopyrans via the semicarbazides 3 and thiosemicarbazides 3 of 2-ethyl-2-methyl-4H-chromen-4-ones 1 by conventional and nonconventional methods. The microwave and ultrasonic irradiation methods form the respective products in excellent yields in very short reaction time as compared to the conventional method. The synthesized compounds were tested for antimicrobial screening against bacteria and fungi show moderate activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.