Trans-N-(2-azido-4-pyridyl)-4-aminomethylcyclohexanecarboxamide | 149004-61-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Trans-N-(2-azido-4-pyridyl)-4-aminomethylcyclohexanecarboxamide
• CAS: 149004-61-5
• 化学式: C₁₃H₁₈N₆O
• 分子量: 274.326
• InChiKey: BXWZANWOGSQYKO-MGCOHNPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  116.77
• 氢给体数：
  2.0
• 氢受体数：
  4.0

文献信息

• Preventives/remedies for kidney diseases
  申请人：——

  公开号：US20030096843A1

  公开（公告）日：2003-05-22

  A compound having a Rho kinase inhibitory activity, such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexane, has a renal interstitial fibrosis inhibitory action in renal interstitial fibrosis model mice and various other actions, and therefore, is useful as an agent for the prophylaxis or treatment of renal diseases.

  具有Rho激酶抑制活性的化合物，例如（+）-trans-4-(1-氨乙基)-1-(4-吡啶基氨甲酰基)-环己烷，对于肾间质纤维化模型小鼠具有肾间质纤维化抑制作用和其他各种作用，因此，可用作预防或治疗肾脏疾病的药物。
• Agent for prophylaxis and treatment of glaucoma
  申请人：——

  公开号：US20030125351A1

  公开（公告）日：2003-07-03

  An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) 1 wherein each symbol is as defined in the specification, as the compound having a Rho kinase inhibitory activity, is provided. The agent for the prophylaxis and treatment of glaucoma of the present invention is a novel agent for the prophylaxis and treatment of glaucoma and has intraocular pressure lowering action, optic disc blood flow improving action and aqueous humor outflow promoting action.

  一种预防和治疗青光眼的药剂，其中包含一种具有Rho激酶抑制活性的化合物，特别是一种预防和治疗青光眼的药剂，其中包含式（I）1的化合物，其中每个符号如规范中所定义，作为具有Rho激酶抑制活性的化合物。本发明的预防和治疗青光眼的药剂是一种新型的预防和治疗青光眼的药剂，具有降低眼内压、改善视盘血流和促进房水排出的作用。
• Pharmaceutical agent containing Rho kinase inhibitor
  申请人：——

  公开号：US20020032148A1

  公开（公告）日：2002-03-14

  A Rho kinase inhibitor is provided as a novel pharmaceutical agent, particularly as a therapeutic agent of hypertension, a therapeutic agent of angina pectoris, a suppressive agent of cerebrovascular contraction, a therapeutic agent of asthma, a therapeutic agent of peripheral circulation disorder, a prophylactic agent of immature birth, a therapeutic agent of arteriosclerosis, an anti-cancer drug, an anti-inflammatory agent, an immunosuppressant, a therapeutic agent of autoimmune disease, an anti-AIDS drug, a contraceptive, a prophylactic agent of digestive tract infection, a therapeutic agent of osteoporosis, a therapeutic agent of retinopathy and a brain function improving drug. In addition, the Rho kinase inhibitor is provided as a reagent and a diagnostic.

  提供了一种新型药物代理——Rho激酶抑制剂，特别用于治疗高血压、心绞痛、脑血管收缩抑制剂、哮喘、周围循环障碍的治疗剂、早产预防剂、动脉硬化的治疗剂、抗癌药物、抗炎剂、免疫抑制剂、自身免疫疾病的治疗剂、抗艾滋病药物、避孕药、消化道感染预防剂、骨质疏松症的治疗剂、视网膜病的治疗剂和脑功能改善药物。此外，Rho激酶抑制剂还可作为试剂和诊断工具。
• Visual function disorder improving agents
  申请人：Takayama Yoshiko

  公开号：US20060148852A1

  公开（公告）日：2006-07-06

  The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.

  本发明提供了一种视觉功能障碍改善剂，其含有一种具有Rho激酶抑制活性的化合物，特别是(R)-(+)-N-(1H-吡咯[2,3-b]吡啶-4-基)-4-(1-氨乙基)苯甲酰胺作为有效成分。该剂具有促进视网膜神经节细胞轴突延伸和视神经细胞再生的作用，可用于治疗由视网膜或视神经的损伤、缺陷、退化等引起的各种眼部疾病相关的视觉功能障碍。
• 4-AMINO(ALKYL)CYCLOHEXANE-1-CARBOXAMIDE COMPOUND AND USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0641781A1

  公开（公告）日：1995-03-08

  A 4-amino(alkyl)cyclohexane-1-carboxamide compound represented by general formula (I), an isomer thereof, and a pharmaceutically acceptable acid addition salt thereof, wherein each symbol is as defined in the specification. These substances have a remarkable, highly persistent and lowly toxic activity of increasing blood stream in coronary, cerebral, renal and peripheral arteries, and are useful as a potent and persistent hypotensive and a drug for preventing and treating diseases of a cardiovascular system such as coronary, cerebral, renal and peripheral arteries. Furthermore, they are useful as an antasthmatic, because they have activities of inhibiting experimental guinea pig asthma caused by the inhalation of histamine and inhibiting contraction of a specimen of an extirpated guinea pig trachea caused by acetylcholine.

  一种由通式(I)代表的 4-氨基(烷基)环己烷-1-甲酰胺化合物、其异构体及其药学上可接受的酸加成盐，其中各符号如说明书中所定义。这些物质在增加冠状动脉、脑动脉、肾动脉和外周动脉血流方面具有显著、高持久性和低毒性的活性，可用作强效持久的降压药以及预防和治疗冠状动脉、脑动脉、肾动脉和外周动脉等心血管系统疾病的药物。此外，它们还可用作抗哮喘药，因为它们具有抑制由吸入组胺引起的实验性豚鼠哮喘和抑制由乙酰胆碱引起的已切除豚鼠气管标本收缩的活性。