difluoro(trimethyl)silane | 142208-17-1

• 分子结构分类: 有机化合物 - 有机金属化合物
• 英文名称: difluoro(trimethyl)silane
• 英文别名: Difluoromethyl-dimethyl-silane；Difluoromethyl(dimethyl)silane
• CAS: 142208-17-1
• 化学式: C₃H₈F₂Si
• 分子量: 110.179
• InChiKey: GJNZQWZGLHQGPC-UHFFFAOYSA-N

物化性质

• 沸点：
  27.4±35.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-氟-2-甲氧基-3-吡啶甲醛 、 difluoro(trimethyl)silane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以7.6 %的产率得到2,2-difluoro-1-(5-fluoro-2-methoxy-3-pyridyl)ethanol
  参考文献：
  名称：

  [EN] SMALL MOLECULE MODULATORS OF IL-17
  [FR] MODULATEURS À PETITES MOLÉCULES D'IL-17

  摘要：

  The present invention relates to a compound according to formula (I), and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  公开号：

  WO2023111181A1
• 作为产物：
  描述：

  (difluoromethyl)silane 反应 7.0h， 以6%的产率得到甲基三氟硅烷
  参考文献：
  名称：

  The synthesis and properties of (CH2F)SiH3 and related monofluoromethylsilanes

  摘要：

  The reduction of (CFCl2)SiCl3 by LiAlH4, Me3SnH, and (nBu)3SnH has been studied. The compound (CH2F)SiH3 (I) and all the compounds of the series (CFCl2-mHm)SiCl3-nHn, m = 0, 1 and n = 0-3 were detected and characterized by NMR spectroscopy. Conditions for the synthesis of I, (CHFCl)SiH3 (IX) and (CFCl2)SiH3 (V) with acceptable yields have been optimized. These novel compounds were studied by H-1, F-19, C-13 and Si-29 NMR spectroscopy; their infrared and Raman spectra were recorded and assigned with the assistance of a normal coordinate analysis of I and its isotopomer (CD2F)SiD3. The thermolyses of I, IX and (CHF2)SiH3 (X) which start at about 120, 200 and 180-degrees-C, respectively, have been studied. Whereas I decomposes by a migration of F from C to Si, compound X undergoes elimination of the carbene CHF, insertion of which into SiH bonds ultimately gives CH3Si derivatives.

  DOI：

  10.1016/0022-328x(92)80068-9