高纯二甲基镉 | 506-82-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡金属化合物
• 中文名称: 高纯二甲基镉
• 中文别名: 二甲基铬；二甲鎘；二甲基镉
• 英文名称: cadmium(2+),carbanide
• 英文别名: dimethylcadmium；cadmium dimethyl；dimethyl cadmium
• CAS: 506-82-1
• 化学式: C₂H₆Cd
• 分子量: 142.48
• InChiKey: KVVGSXJGEUULNM-UHFFFAOYSA-N

物化性质

• 熔点：
  -4,5°C
• 沸点：
  105,5°C
• 密度：
  1,986 g/cm3
• 闪点：
  -18°C
• 稳定性/保质期：

  在空气中容易氧化自燃，与水接触会发生剧烈反应。

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  3.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

安全信息

• TSCA：
  Yes
• 危险等级：
  4.2
• 安全说明：
  S16,S23,S36/37/39,S45,S7/8
• 危险类别码：
  R17,R20/21/22
• 海关编码：
  2931900090
• 危险类别：
  4.2
• 危险品运输编号：
  UN 2845
• 储存条件：
  实用中考虑到金属粒子污染，采用内壁涂层的不锈钢鼓泡瓶封装，确保阀门接管畅通，瓶内空间充高纯氮气保护，然后关严阀门、拧紧封头。高纯二甲基镉应储存在冰箱中。危险货物包装标志需符合GB190规定，包装和贮运指示标志则需符合GB191规定。产品出口时的运输参照美国DOT规则GFR部分的相关规定执行。运输过程中，瓶外应用充氮气的软包装袋保护，并放入塑料袋中，再封入内衬有无机防火材料的铁盒中，最后固定在木箱中。使用二甲基镉时应遵守可燃、有毒物质使用的安全规定及“通则”中的相关规定。其他安全注意事项参见二乙基碲。

SDS

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Section 1: Product Identification
Chemical Name: Dimethylcadmium, elec. gr. (99.995+%-Cd) PURATREM **S.STEEL CYL EXTRA**
CAS Registry Number: 506-82-1
Formula: (CH3)2Cd
EINECS Number: none
Chemical Family: metal alkyl
Synonym: None

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 506-82-1 100% 0.002mg/m3 0.005mg/m3

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Section 3: Hazards Identification
The oral toxicity of cadmium and its compounds is high. The inhalation of cadmium fumes and dust can lead
Emergency Overview:
to effects on the respiratory tract and the kidneys. May cause cancer.
Primary Routes of Exposure: Ingestion, inhalation
Eye Contact: May cause mild to severe irritation of the eyes.
Skin Contact: May cause mild to severe irritation of the skin.
Inhalation of fumes can lead to a cough, headache, shortness of breath and vomiting. Severe exposure can
Inhalation:
lead to dyspnea. Toxic by inhalation.
Ingestion may lead to dizziness, abdominal cramps, vomiting, bloody diarrhea, weakness, and convulsions.
Ingestion:
Toxic if swallowed.
Acute Health Affects: May be irritating to skin, eyes and respiratory tract. Toxic by inhalation and if swallowed.
Long term exposure to cadmium and cadmium compounds can lead to effects of the respiratory tract and
Chronic Health Affects:
kidney damage. Cadmium is a recognized carcinogen of the connective tissue, lungs and the liver.
NTP: Yes
IARC: Yes
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: -1°F
Autoignition Temperature: None
Explosion Limits: None
Extinguishing Medium: Foam or dry powder
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material can emit irritating and toxic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: Material is pyrophoric. The material will ignite on contact with air.

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SECTION 6: Accidental Release Measures
If spilled, the material will ignite emitting iritating and toxic fumes. All personnel must evacuate the area.
Spill and Leak Procedures: Emergency crews must be fitted with self-contained breathing apparatus. Burning material can be quenched
with dry powders such as dolomite of sodium carbonate.

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SECTION 7: Handling and Storage
The product must be stored and handled under an inert atmosphere of nitrogen or argon. Keep away from
Handling and Storage:
heat.

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SECTION 8: Exposure Controls and Personal Protection
Always wear approved safety glasses when handling a chemical substance in the laboratory. Use of a face
Eye Protection:
shield is highly recommended.
Skin Protection: Protective gloves and protective clothing must be worn when handling this product.
Product must be handled in an inert atmosphere. In the event of a spill or release, adequate ventilation is
Ventilation:
essential.
If the potential exists for a spill or release of this product, workers should be equipped with a self-contained
Respirator:
breathing apparatus.
Product must be handled in an inert atmosphere. In the event of a spill or release, adequate ventilation is
Ventilation:
essential.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: Colorless liq.
Molecular Weight: 142.88
Melting Point: none
Boiling Point: 105.5°C
Vapor Pressure: 28mm (20°C)
Specific Gravity: 1.985 (18°)
Odor: metallic odor
Solubility in Water: Reacts vigorously with water

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SECTION 10: Stability and Reactivity
Stability: Moisture sensitive, pyrophoric
Hazardous Polymerization: No hazardous polymerization
Conditions to Avoid: Contact with air.
Water, alcohols, carbonyl compounds, mineral acids, metal salts, sulfur, phosphorus, metals and chlorinated
Incompatibility:
hydrocarbons
Decomposition Products: carbon dioxide, carbon monoxide, and cadmium oxide fumes.

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SECTION 11: Toxicological Information
RTECS Data: No specific information available from the RTECS files.
Carcinogenic Effects: No data available
Mutagenic Effects: Possible mutagenic effects reported by RTECS
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: Cadmium is a toxic material and represents a hazard to aquatic life.

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Organometallic substance,Liquid,Pyrophoric,Water-reactive
Hazard Class (CFR): 4.2
Additional Hazard Class (CFR): 4.3
Packaging Group (CFR): I
UN ID Number (CFR): UN# 3394
Shipping Name (IATA): Prohibited
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): UN# 3394

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SECTION 15: Regulatory Information
TSCA: Not listed in TSCA inventory
SARA (Title 313): Title Compound: See Category Code N078 for reporting.
Second Ingredient: None

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生产方法是将镉的卤化物与新鲜的格氏试剂反应，合成的粗产品经过二级精馏提纯后可获得高纯度的二甲基镉产品。

反应信息

• 作为反应物：
  描述：

  高纯二甲基镉 在 iron(III)-acetylacetonate 氧气 作用下， 以 癸烷 为溶剂， 生成 methyl(methylperoxy)cadmium
  参考文献：
  名称：

  Aleksandrov, Yu. A.; Lebedev, S. A.; Baranov, E. A., Journal of general chemistry of the USSR, 1988, vol. 58, p. 2229 - 2232

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基碘化镁 在 cadmium(II) chloride 作用下， 生成 高纯二甲基镉
  参考文献：
  名称：

  Investigation of an Abnormal Organocadmium Reaction¹

  摘要：

  DOI：

  10.1021/ja01525a044
• 作为试剂：
  描述：

  α-phenylcinnamoyl chloride 在 甲醇 、 sodium tetrahydroborate 、 正己烷 、 高纯二甲基镉 、 苯 作用下， 生成 3,4-diphenyl-3-buten-2-ol
  参考文献：
  名称：

  Overlap Control of Carbanionoid Reactions. I. Stereoselectivity in Alkaline Epoxidation

  摘要：

  DOI：

  10.1021/ja01510a024

文献信息

• Selenoesters in organic synthesis. 1. A novel synthesis of ketones.
  作者：A.F. Sviridov、M.S. Ermolenko、D.V. Yashunsky、N.K. Kochetkov

  DOI：10.1016/s0040-4039(00)88340-9

  日期：1983.1

  A mild and efficient esters into ketones transformation via selenoesters have been described.

  已经描述了一种温和有效的酯，其通过硒酸酯转化成酮。
• Synthese directe de phosphines tertiaires racemiques et de chlorophosphines dissymetriques
  作者：W. Chodkiewicz、D. Guillerm、D. Jore、E. Mathieu、W. Wodzki

  DOI：10.1016/0022-328x(84)80288-0

  日期：1984.7

  Racemic tertiary phosphines are obtained from dichlorophenylphosphine by a “one pot” synthesis in two steps: (1) condensation of one equivalent of an organocadmium, and (2) substitution of the second chlorine by another organometallic compound.

  外消旋的叔膦是通过“一锅法”合成通过两个步骤从二氯苯基膦获得的：两个步骤：（1）缩合一当量的有机镉，以及（2）第二氯被另一种有机金属化合物取代。
• Spectroscopy of unstable complexes of organometallic compounds with small molecules at low temperatures
  作者：B.V. Lokshin、I.I. Greenwald

  DOI：10.1016/0022-2860(90)80003-3

  日期：1990.5

  Abstract Using IR spectroscopy, evidence has been obtained that organometallic compounds of transition metals (metallocenes, arenemetaltricarbonyls) and of non-transition elements (alkyl derivatives of II–V group elements) are capable of forming unstable complexes with small molecules (N 2 , O 2 , H 2 , CH 4 ), which can be stabilized at low temperatures. The structure determination of the complexes

  摘要 使用红外光谱，已经获得证据表明过渡金属（茂金属、芳烃金属三羰基）和非过渡元素（II-V 族元素的烷基衍生物）的有机金属化合物能够与小分子（N 2 、O 2 , H 2 , CH 4 )，可在低温下稳定。讨论了使用同位素取代化合物光谱数据确定配合物的结构。
• Potential precursors to electronic materials: three coordinate cadmium in [MeCd(.mu.-tert-Bu2P)]3, the first cadmium diorganophosphide
  作者：Brian L. Benac、Alan H. Cowley、Richard A. Jones、Christine M. Nunn、Thomas C. Wright

  DOI：10.1021/ja00195a067

  日期：1989.6

  of such molecules are (Mesub 2}-Ga(mu}-t-Busub 2}As))sub 2} and (Mesub 2}In(mu}-t-Busub 2}P))sub 2}. They have also sought routes to II/V semiconductors such as Znsub 3}Psub 2}, Cdsub 3}Psub 2}, and CdPsub 2} which are used for doping photoelectrics. The authors have recently discovered that the reactive, mononuclear binary phosphido compound Ga(t-Busub 2}P)sub 3} acts as a smooth phosphido

  作为专注于电子材料前体设计和合成的项目的一部分，作者和其他人最近展示了使用单源分子来生长 III/V 族化合物半导体，例如 GaAs 和 InP。他们用于 III/V 半导体的方法是通过强的双中心双电子键将两种元素结合成同一分子，并采用易于分解过程（例如 β}-氢消除）的配体。这种分子的例子是 (Mesub 2}-Ga(mu}-t-Busub 2}As))sub 2} 和​​ (Mesub 2}In(mu}-t-Busub 2}P))sub 2}。他们还寻求获得 II/V 半导体的途径，例如用于掺杂光电的 Znsub 3}Psub 2}、Cdsub 3}Psub 2} 和​​ CdPsub 2}。作者最近发现，反应性、单核二元磷基化合物 Ga(t-Busub 2}P)sub 3} 可作为主要基团和过渡金属物种的平滑磷基转移试剂。作者在此描述了 1-3 的合成以及
• Progestin 16.alpha.,17.alpha.-dioxolane ketals as molecular probes for the progesterone receptor: synthesis, binding affinity, and photochemical evaluation
  作者：Philip R. Kym、Kathryn E. Carlson、John A. Katzenellenbogen

  DOI：10.1021/jm00061a001

  日期：1993.4

  progesterone = 13%, R5020 = 100%) and photoinactivation efficiency (6 = 80%, 8 = 77%, 9 = 29% at 30 min) required for potential photoaffinity labeling reagents for the PgR. The synthesis of azide 6 has been modified to accommodate a palladium-catalyzed tritium gas hydrogenolysis of an iodoaryl precursor in the final stage of the synthetic sequence; this procedure has been verified by hydrogenation.

  业已证明，类固醇受体的化学探针可用于提供有关重要激素-受体相互作用的分子细节。已制备了一系列与天然孕酮相比具有更高亲和力的与孕酮受体（PgR）结合的苯乙酮或取代的苯乙酮的孕激素的16种α，17α-二氧戊环缩酮，并已在体外和体内进行了评估孕激素受体的探针。对叠氮基苯乙酮缩酮6，四氟类似物8和对-（苯甲酰基）苯乙酮缩酮9证明了所需的高相对结合亲和力（RBA）组合（6 = 15％，8 = 14％，9 = 6.6％，黄体酮PgR的潜在光亲和标记试剂所需的光灭活效率（13％，R5020 = 100％）和光灭活效率（6 = 80％，8 = 77％，9 = 29％在30分钟时）。叠氮化物6的合成已被修改，以适应在合成序列的最后阶段钯催化的碘代芳基前体的gas气氢解；该方法已经通过氢化验证。另外，基于其对PgR的高亲和力（RBA ＝ 53％），选择了孕激素对氟苯乙酮缩酮10以氟-18标记的形式制备。氟18

表征谱图