7-propylbenzo[b]thiophene | 188788-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 7-propylbenzo[b]thiophene
• 英文别名: Benzothiophene, 7-propyl；7-propyl-1-benzothiophene
• CAS: 188788-76-3
• 化学式: C₁₁H₁₂S
• 分子量: 176.282
• InChiKey: KSEVTJMRWLUUIL-UHFFFAOYSA-N

物化性质

• 保留指数：
  1471.7

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 silver tetrafluoroborate 、 三苯基膦氯金 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以76.3 mg的产率得到7-propylbenzo[b]thiophene
  参考文献：
  名称：

  苯并[ b ]噻吩，苯并[ b ]呋喃和二苯并呋喃的一般合成方法是通过金催化的1-杂芳基烷基-2,3-二烯基乙酸酯的环化反应

  摘要：

  通过金催化的1-杂芳基烷基-2,3-二烯基乙酸酯的苯并环烷基化反应，开发了一种高效温和的途径来制备一系列苯并[ b ]噻吩，苯并[ b ]呋喃和二苯并呋喃。在机理研究的基础上，提出了该反应涉及金卡宾和芳基金中间体的两种可能途径。

  DOI：

  10.1016/j.tet.2013.04.099

文献信息

• NICOTINAMIDES AS JAK KINASE MODULATORS
  申请人：Bauer Shawn M.

  公开号：US20120108566A1

  公开（公告）日：2012-05-03

  The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

  本发明涉及具有公式I的化合物及其药用可接受的盐、酯和前药，这些化合物是JAK激酶的抑制剂。本发明还涉及用于制备这类化合物的中间体，该化合物的制备，含有该化合物的药物组合物，抑制JAK激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗至少部分由JAK激酶活性介导的多种疾病条件的方法，例如不良血栓形成和非霍奇金淋巴瘤。
• Composition containing carbon nanotubes having coating thereof and process for producing them
  申请人：Saitoh Takashi

  公开号：US20060052509A1

  公开（公告）日：2006-03-09

  The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

  本发明的目的是提供一种碳纳米管组合物，不会影响碳纳米管本身的特性，使碳纳米管可以分散或溶解在溶剂中，在长期储存期间不会导致碳纳米管分离或聚集，具有优异的电导性、成膜性和成型性，可以轻松地涂覆或覆盖在基材上，所得到的涂层膜具有优异的防潮性、耐候性和硬度；一种由涂层膜组成的复合材料；以及它们的生产方法。为了实现这一目的，本发明提供了一种碳纳米管组合物，其中包含导电聚合物(a)或杂环化合物三聚体(i)、溶剂(b)和碳纳米管(c)，并可根据需要另外包含高分子量化合物(d)、碱性化合物(e)、表面活性剂(f)、硅烷偶联剂(g)和胶体二氧化硅(h)；一种由该组合物组成的涂层膜复合材料；以及它们的生产方法。
• Carbon Nanotube Composition, Composite Having a Coated Film Composed of the Same, and Their Production Methods
  申请人：SAITOH Takashi

  公开号：US20090321688A1

  公开（公告）日：2009-12-31

  The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

  本发明的目的是提供一种碳纳米管组合物，不会损害碳纳米管本身的特性，可以使碳纳米管分散或溶解于溶剂中，在长期存储期间不会导致碳纳米管分离或聚集，具有优异的电导率、膜成形性和成型性，可以轻松涂覆或覆盖在基材料上，并且所得到的涂层膜具有优异的防潮性、耐候性和硬度；一种由该组合物组成的涂层膜复合材料；以及它们的生产方法。为了实现这一目的，本发明提供了一种碳纳米管组合物，它包含导电聚合物(a)或杂环化合物三聚体(i)、溶剂(b)和碳纳米管(c)，并可以根据需要另外包含高分子化合物(d)、碱性化合物(e)、表面活性剂(f)、硅烷偶联剂(g)和胶体二氧化硅(h)；一种由该组合物组成的涂层膜复合材料；以及它们的生产方法。
• ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
  申请人：National University Corporation Hokkaido University

  公开号：EP3815689A1

  公开（公告）日：2021-05-05

  The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound. An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof: (wherein R1 is carboxy, or the like; A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like; R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR5R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10R11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

  本发明提供了一种具有抗病毒活性的化合物，尤其是具有抑制禽流感病毒增殖活性的化合物，和/或包含该化合物的药物。更优选地，本发明提供了一种化合物，该化合物对旧大陆病毒（如卢纳病毒、拉萨病毒和淋巴细胞色素膜炎病毒）和/或新大陆病毒（如朱宁病毒）具有增殖抑制活性，和/或包含该化合物的药物。 一种由式（I）代表的化合物或其原药或其药学上可接受的盐组成的腺病毒增殖抑制剂： (其中 R1 是羧基或类似物；A3 是 CR2 或 N；R2 是氢原子、卤素、羟基或类似物；R3 是氢原子、羟基、羧基、氰基、甲酰基、任选被取代基 F 取代的烷基或类似物；A1 或 A2 是 CR5R6，另一个是 NR7，或 A1 是 CR8R9，A2 是 CR10R11；以及 R5、R6、R7、R8、R9、R10 和 R11 各自独立地是氢原子、羧基、氰基、任选被取代基 F 取代的烷基或类似基团）。
• PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
  申请人：SomaLogic, Inc.

  公开号：US10544419B2

  公开（公告）日：2020-01-28

  Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.

  本研究提供了对结合 PDGF 的核酸酶和结合 VEGF 的适配体具有更高抗稳定性的适配体。此外，还提供了包含 PDGF 拟合物和 VEGF 拟合物的拟合物构建体。本发明还提供了包含该适配体和适配体构建体的药物组合物，以及使用该适配体和适配体构建体治疗疾病的方法。