2-(2,2-Difluorobutylamino)ethanol | 1149341-68-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2,2-Difluorobutylamino)ethanol
• CAS: 1149341-68-3
• 化学式: C₆H₁₃F₂NO
• 分子量: 153.172
• InChiKey: RWUUNQSPKZGOQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 5-(4-chlorophenyl)-1-(2-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate 、 2-(2,2-Difluorobutylamino)ethanol 反应 18.0h， 生成
  参考文献：
  名称：

  Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

  摘要：

  We report the design, synthesis, and structure-activity relationships of novel bicyclic lactam-based cannabinoid type 1 (CB,) receptor antagonists. Members of these series are potent, selective antagonists in in vitro/in vivo efficacy models of CB, antagonism and exhibit robust oral activity in rodent models of food intake. These efforts led to the identification of 19d, which has been advanced to human clinical trials for weight management.

  DOI：

  10.1021/jm900255t

文献信息

• RESIST COMPOSITION AND PATTERNING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20180101094A1

  公开（公告）日：2018-04-12

  A resist composition comprising a base polymer and a metal salt of carboxylic acid or sulfonamide is provided, the metal being selected from calcium, strontium, barium, cerium, aluminum, indium, gallium, thallium scandium, and yttrium. The resist composition exhibits a sensitizing effect and an acid diffusion suppressing effect and forms a pattern having improved resolution, LWR and CDU.
• US9897914B2
  申请人：——

  公开号：US9897914B2

  公开（公告）日：2018-02-20
• US9958776B2
  申请人：——

  公开号：US9958776B2

  公开（公告）日：2018-05-01