(3S,4R)-4-benzylpyrrolidin-3-ol | 215922-83-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3S,4R)-4-benzylpyrrolidin-3-ol
• CAS: 215922-83-1
• 化学式: C₁₁H₁₅NO
• 分子量: 177.24
• InChiKey: XOLLUCNYIRMTHL-GHMZBOCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE<br/>[FR] INHIBITEURS DE LA MYÉLOPEROXYDASE À BASE DE TRIAZOLOPYRIDINES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017160632A1

  公开（公告）日：2017-09-21

  The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

  本发明提供了式（I）的化合物。其中A和Z如规范中所定义，并包括任何这类新化合物的组合物。这些化合物是髓过氧化物酶（MPO）抑制剂，可能对动脉粥样硬化、心力衰竭、慢性阻塞性肺病（COPD）及相关疾病的治疗和/或预防有用。
• Triazolopyridine inhibitors of myeloperoxidase
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11059818B2

  公开（公告）日：2021-07-13

  The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

  本发明提供了式(I)化合物，其中A和Z如说明书中所定义，以及包含任何此类新型化合物的组合物。这些化合物是髓过氧化物酶（MPO）抑制剂，可用于治疗和/或预防动脉粥样硬化、心力衰竭、慢性阻塞性肺病（COPD）及相关疾病。
• TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE
  申请人：Bristol-Myers Squibb Company

  公开号：US20200291015A1

  公开（公告）日：2020-09-17

  The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.